1384P - Clinical characteristics and psychological associations of cancer chemotherapy-related side effects in patients with lung cancer

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anticancer Agents
Complications/Toxicities of Treatment
Thoracic Malignancies
Biological Therapy
Presenter Min Li
Citation Annals of Oncology (2014) 25 (suppl_4): iv481-iv485. 10.1093/annonc/mdu352
Authors M.M. Li1, X. Lou2, Y. Zhou3, L. Zhou4
  • 1Department Of Medical Oncology, Cancer Center, State Key Laboratory Of Biotherapy, West China Hospital, Sichuan University, 610041 - Chengdu/CN
  • 2Department Of Nursing Psychology, West China Hospital, Chengdu/CN
  • 3Department Of Preventive Medicine, West China School of Public Health, Chengdu/CN
  • 4Department Of Thoracic Cancer, Cancer Center, West China Hospital of Sichuan University, 610041 - Chengdu/CN



Psychological distress and chemotherapy-related side effects frequently co-occur in patients with lung cancer (LC). Clinical experience suggests that LC is associated with psychological distress that may contribute to worse chemotherapy-related side effects. Using questionnaires, we tried to describe clinical characteristics of psychological distress and chemotherapy-related side effects, and to examine the influence of psychological distress on side effects among LC patients during chemotherapy.


Patients with LC receiving chemotherapy completed an assessment that captured clinical characteristics, psychological state (anxiety, depression and insomnia) and treatment-related side effects (nausea, vomiting, constipation and fatigue). Psychological distress was assessed by Hospital Anxiety and Depression Scale and by Pittsburgh Sleep Quality Index (PSQI). Nausea, vomiting and constipation were examined as defined by the National Cancer Institute Common Terminology Criteria for Adverse Events, while fatigue was scored on a 10-point scale ranging from 0 =“not present” to 10 = “as bad as you can imagine”.


In total, 93 patients with a mean age of 58 years joined this study. Grade 0 to 3 toxicity occurred in 100% of the patients. Patients with LC who were younger than 58 years, female, retired from work, and had less medical insurance were significantly likely to experience more severe vomiting (p = 0.018), constipation (p = 0.004), fatigue (p = 0.004) and nausea (p = 0.047). On the other side, patients with LC who were female, had poor living conditions, and retired from work were significantly likely to experience more severe insomnia (p = 0.014), anxiety and depression (p = 0.030 and p = 0.004 respectively) and insomnia (p = 0.002). Those with more severe depression complaints had significantly more vomiting (p = 0.035), while those with more severe anxiety and insomnia complaints had significantly more fatigue (p = 0.038 and p = 0.000 respectively).


Psychological distress is a prevalent problem in LC and it was associated with an increased treatment-related side effect during chemotherapy. Improving psychological health can be a possible solution to decrease chemotherapy-related side effects so that may reduce treatment interruptions, improve the cure rate and increase quality of life following treatment.


All authors have declared no conflicts of interest.