1555TiP - ACCeRT: Auckland's cancer cachexia evaluating resistance training study

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Supportive Measures
Presenter Elaine Rogers
Citation Annals of Oncology (2014) 25 (suppl_4): iv517-iv541. 10.1093/annonc/mdu356
Authors E.S. Rogers1, R. Sasidharan2, G.M. Sequeira3, M.R. Wood4, S.P. Bird5, B. Arroll6, J. Stewart6, J.W.L. Keogh7, R.D. Macleod8
  • 1Faculty Of Medical And Health Sciences, The University of Auckland, 1014 - Auckland/NZ
  • 2Medical Oncology, Auckland City Hospital, Auckland/NZ
  • 3School Of Sport, Manukau Institute of Technology, Auckland/NZ
  • 4Sport And Recreation, Auckland University of Technology, Auckland/NZ
  • 5Strength And Conditioning, Charles Sturt University, Bathurst/AU
  • 6Faculty Of Medical And Health Sciences, The University of Auckland, Auckland/NZ
  • 7Exercise And Sports Science, Bond University, Gold Coast/AU
  • 8Palliative Care, The University of Sydney, Sydney/AU



Cancer Cachexia (CC) is a common problem seen in many advanced malignancies including Non- Small-Cell Lung Cancer (NSCLC). In CC there is a significant loss of adipose tissue and skeletal muscle mass. Muscle wasting is the main cause of impaired function, leading to respiratory complications and fatigue. The optimal treatment for CC is the complete removal of the tumour; unfortunately with advanced NSCLC this is unachievable. The next best options are to increase nutritional intake to counteract weight loss, address the anorexia, inflammation, and metabolic alterations i.e. loss of body fat and the skeletal muscle wasting. This requires the need to utilise a multi-targeted approach to decrease the inflammation and to stimulate the skeletal anabolic pathways with the use of progressive resistance training (PRT). PRT has shown acceptability and benefits in other cancer populations. This study aims to identify a novel multi-targeted treatment regimen that will alleviate and/or stabilise CC weight loss.

Trial design

Methods: This is a randomised, open-label study to investigate whether 2 sessions each week of PRT followed by essential amino acids (EAA’s) high in leucine, when administered in addition to Eicosapentaenoic Acid (EPA) and a Cox-2 inhibitor is acceptable to NSCLC cachectic patients for a period of 20 weeks (primary endpoint). Secondary endpoints include Lean Body Mass, MRI thigh skeletal muscle values, QoL and Fatigue questionnaires, serum pro-inflammatory cytokine profiles, and hand and leg strength. Safety data will also be collected. Outcome measures to power a future study will be determined from the trend in difference between the two groups. 21 patients are planned to be randomised in a 1:2 ratio Arm A EPA and Cox-2 inhibitor vs. Arm B EPA, Cox-2 inhibitor, PRT followed by EAA’s. All patients are offered to continue with the study medications and/or PRT sessions on compassionate use. Main inclusion criteria include: histological proven NSCLC patients who have at least 5% weight loss and fulfil the following cachectic definition (Evans Clin Nut 2008 27). A guest patient was enrolled in May 2012, followed by study participants in June 2012.


S.P. Bird: Disclosure: Stephen P Bird is a consultant to Musashi Performance Nutrition. All other authors have declared no conflicts of interest.