62P - Risk factors associated with early vs late recurrence in stage I lung adenocarcinoma

Date 07 May 2017
Event ELCC 2017
Session Poster Display Session
Topics Thoracic Malignancies
Presenter JIE Qian
Citation Annals of Oncology (2017) 28 (suppl_2): ii20-ii23. 10.1093/annonc/mdx085
Authors J. Qian1, J. Xu1, S. Wang1, W. Yang1, F. Qian1, B. Zhang1, R. Wang2, X. Zhang1, H. Wang1, B. Han1
  • 1Department Of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, 200030 - Shanghai/CN
  • 2Department Of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, 200030 - Shanghai/CN

Abstract

Background

Patients with stage I lung adenocarcinoma (ADC) develop recurrences after complete surgical resection, both early and over the long term. This study aimed to identify and compare risk factors for early and late recurrence after surgery in stage I lung ADC patients.

Methods

We analyzed recurrences among 5904 patients with stage I lung ADC who underwent curative operations at Shanghai Chest Hospital between January 1, 2008 and December 31, 2014. Recurrences were classified as within 2 years (early), and more than 2 years (late) after surgery. The clinicopathologic findings were compared between patients with early and late recurrences. Both univariate and multivariate analyses were performed, incorporating factors of gender, age at diagnosis, operation type, tumor location and size, pathologic subtype, cell differentiation, lymphovascular invasion, visceral pleural invasion, and smoking history.

Results

Recurrence occurred in totally 628 (10.6%) patients, with early and late recurrence in 300 and 328 patients, respectively. Early and late recurrences shared common risk factors of advanced age at diagnosis (P = 0.013 and P = 0.006, respectively), poorly cell differentiation (both P = 0.000), larger tumor size (both P = 0.000), and visceral pleural invasion (both P = 0.000). Early recurrence was additionally associated with male (HR, 1.327; 95%CI, 1.042-1.690; P = 0.022), sublobar resection (HR, 2.353; 95%CI, 1.634-3.387; P = 0.000), tumor located in the right middle lobe (HR, 1.711; 95%CI, 1.634-3.387; P = 0.005) and solid, micropapillary or variant subtypes (HR, 5.437; 95%CI, 1.258-23.509; P = 0.023).

Conclusions

These findings suggest the existence of different risk factors accounting for early vs late recurrences among patients with stage I lung ADC.

Clinical trial identification

Legal entity responsible for the study

Shanghai Chest Hospital

Funding

Shanghai Chest Hospital

Disclosure

All authors have declared no conflicts of interest.