153P - Predictive markers of survival in patients with pulmonary metastases and malignant pleural effusion
Date | 07 May 2017 |
Event | ELCC 2017 |
Session | Poster Display Session |
Topics | Thoracic Malignancies |
Presenter | Franco Lumachi |
Citation | Annals of Oncology (2017) 28 (suppl_2): ii52-ii55. 10.1093/annonc/mdx094 |
Authors |
F. Lumachi1, S.M. Basso2, R. Tozzoli3, A. Del Conte4, U. Zuccon5, P. Ubiali6
|
Abstract
Background
Lung metastases (LMs) can be identified in up to 30-50% of all cancer patients, and represent the result of metastatic spread to the lungs from the several cancers. The presence of LMs seriously affects overall survival (OS), and the onset of pleural effusion further reduces the life expectancy of the patients. The aim of this retrospective study was to evaluate the usefulness of carcinoembryonic antigen (CEA), lactate dehydrogenase (LDH), and C-reactive protein (CRP) measurement in the pleural fluid of patients with LMs and malignant pleural effusion (MPE).
Methods
The medical records of 22 patients (median age 68 years, range 46-86) with LMs (mainly from breast, urinary tract, and colorectal cancers) and MPE were analyzed. There were 13 (59.1%) males and 9 (40.9%) females. All patients underwent video-assisted thoracoscopic (VAT)-assisted thoracentesis and subsequent pleural fluid examination, including CEA, LDH, and CRP, which were measured using a chemiluminescent (CLIA) immunoassay (sandwich CLIA with native CEA coated to magnetic microbeads), a spectrophotometric assay (L-lactate as substrate), and an immunonephelometric assay (polystyrene particles coated with anti-human CRP monoclonal antibodies), respectively.
Results
The OS was 6.7±5.2 months (range 1-23 months), and the levels of pleural markers were 10.4±21.6 ng/mL (CEA), 418.4±342.9 U/L (LDH), and 6.2±9.1 mg/L (CRP). No relationship was found between OS and the age of the patients (R = 0.14, p = 0.542), LDH (R=-0.31, p = 0.169) or CRP (R=-0.33, p = 0.136). There was a significant direct correlation between OS and CEA (R = 0.66, p = 0.0007). The relative regression line equations are reported in the table.rnTable: 153Prn
Parameter | rnRegression line equation | rn
---|---|
Age of the patients | rnOS = 63.323797651973 + 0.23725477330884 age | rn
CEA | rnOS = 2.0616207417742-4.4634344843623 CEA | rn
LDH | rnOS = 470.3738751303-20.900941750959 LDH | rn
CRP | rnOS = 12.210673177537-0.84687826996861 | rn
Conclusions
In patients with MPE and LMs, only CEA pleural levels significantly related to OS, and can be considered a useful predictive factor. Further studies will eventually confirm our results.
Clinical trial identification
Legal entity responsible for the study
Università degli Studi di Padova
Funding
Università degli Studi di Padova
Disclosure
All authors have declared no conflicts of interest.