201P - Pattern of metastases and their impact on outcomes in stage IV non small cell lung cancer – an institutional experience from South India

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Metastatic
Presenter Bala Stalin
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors B. Stalin1, S. Gundeti2, A. Kumar1, L.S. Maddali1, R. Kandula1, R. Digumarti3
  • 1Medical Oncology, Nizam's Institute of Medical Sciences, 500082 - Hyderabad/IN
  • 2Dept. Of Medical Oncology, Nizam's Institute of Medical Sciences, 500082 - Hyderabad/IN
  • 3Medical Oncology, Homi Bhabha Cancer Hospital & Research Center, 530046 - Visakhapatnam/IN

Abstract

Background

Non-small cell lung cancer (NSCLC) metastasizes to bone, brain, lung, and liver, causing a shorter survival. Knowledge of metastatic patterns is crucial in treatment of patients. The aim was to study pattern of metastases in stage IV NSCLC, its correlation with gender, smoking status and pathological features and their impact on survival

Methods

Data of patients with metastatic NSCLC diagnosed between 2010 and 2014 was retrospectively analyzed. Univariate and multivariate analysis for OS were done using graphpad prism and MedCalc software

Results

A total of 392 patients were analyzed. The median age was 58 years. The most common site of metastases were opposite lung (33.6%), bone (33.4%), pleural effusion (32.9%) and adrenal gland (17.3%). Liver, brain, pericardial effusion, neoplastic meningitis was seen in 10.7%, 10.2%, 1.8% and 1% of patients respectively. Pattern of metastases in correlation with gender and smoking status is shown in Table 1. There was no significant difference in pattern of metastases with respect to histology and mutational status. Of the 392 patients, 286 received chemotherapy and were analyzed for outcomes. The median progression and overall survival was 8.6 and 12.9 months respectively. On univariate analysis, liver and brain metastasis at presentation significantly predicted outcome (6.4 vs 12.2, p = 0.009 and 5.15 vs 12.5, p 

Conclusions

Pleural effusion, opposite lung and bone are common sites of metastatic disease in NSCLC. Males, smokers had more lung metastases and females, non smokers had more pleural effusion and bone mets. There was no difference in metastatic pattern with respect to histology. Pleural effusion, liver and brain metastases significantly impacted survival

Clinical trial identification

Nil

Legal entity responsible for the study

Department of Medical Oncology, Nizam`s Institute of Medical Sciences, Hyderabad

Funding

Department of Medical Oncology, Nizam`s Institute of Medical Sciences, Hyderabad

Disclosure

All authors have declared no conflicts of interest.