56P - Incidence of glutathione S-transferase M1 and T1 polymorphisms among the smoker populations of Tabuk

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Aetiology, epidemiology, screening and prevention
Basic Scientific Principles
Presenter Rashid Mir
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors R. Mir1, F.M. Abu Duhier2, A.Y. Hamadi2
  • 1Prince Fahd Bin Sultan Research Chair ,cancer Molecular Genetics, Faculty Of Applied Medical Sciences, University of Tabuk, 71491 - Tabuk-Ksa/SA
  • 2Faculty Of Applied Medical Sciences, university of Tabuk, 71491 - Tabuk-Ksa/SA

Abstract

Background

The GSTM1, T1 are involved in the metabolism of xenobiotics that include environmental carcinogens, reactive oxygen species and chemotherapeutic agents. The variability in the distribution of the null phenotypes of GSTM1, T1, due to total or partial gene deletion resulting in the lack of the active enzyme and has been reported in different populations, especially in ethnically well-defined groups but not in Tabuk.

Methods

This study was conducted on 200 subjects of Tabuk among which 100 were smokers and 100 nonsmokers. The subjects were reporting to hospital for routine checkup. All were without past history of any chronic disease and no significant abnormality. GST genotyping was done by multiplex PCR-based methods. The smoker and control groups were compared using a chi-square test with P 

Results

The distribution of the GSTM1 null genotype was more frequent in non smoker (14%) than the smoker (1%) and difference was statistically significant (P 

Conclusions

This is the first study that addresses GST gene polymorphism among the populations of Tabuk (Saudi Arabia) and enables selecting subgroups among the general population who are more susceptible to DNA damage and will help genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and drug effects in Arab population. Studies with a larger sample size are needed to evaluate and confirm the validity of our results.

Clinical trial identification

Legal entity responsible for the study

Prince Fahd Bin Sultan Research Chair

Funding

Prince Fahd Bin Sultan Research Chair

Disclosure

All authors have declared no conflicts of interest.