108P - Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Non-Small Cell Lung Cancer
Translational Research
Basic Principles in the Management and Treatment (of cancer)
Presenter Jin Eun Choi
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors J.E. Choi1, S.K. Do2, M.J. Hong3, J.H. Lee2, J.Y. Park4
  • 1Cell And Matrix Research Institute, Kyungpook National University School of Medicine, 702-210 - Daegu/KR
  • 2Departments Of Biochemistry And Cell Biology, Kyungpook National University School of Medicine, Daegu/KR
  • 3Cell And Matrix Research Institute, Kyungpook National University School of Medicine, Daegu/KR
  • 4Department Of Internal Medicine, Kyungpook National University School of Medicine, Daegu/KR

Abstract

Background

This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection

Methods

Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed.

Results

Among the 44 SNPs investigated, four SNPs (ENO1 rs227****A>G, PFKM rs1116****C>T, PFKP rs11*****C>T, PDK2 rs37*****G>A) were significantly associated with survival outcomes in multivariate analyses. When stratified by tumor histology, three SNPs (ENO1 rs227****A>G, PFKM rs11*****C>T, and PDK2 rs37*****G>A) were significantly associated with OS and/or DFS only in squamous cell carcinoma, whereas PFKP rs11*****C>T exhibited a significant association with survival outcomes only in adenocarcinoma. When the four SNPs were combined, OS and DFS decreased as the number of bad genotypes increased (Ptrend = 9×10–4 and 2×10–5, respectively). Promoter assays showed that ENO1 rs227****G allele had significantly higher promoter activity compared to the rs227****A allele (P = 3×10–4).

Conclusions

The four SNPs, especially ENO1 rs227****A>G, may be useful for the prediction of prognosis in patients with surgically resected NSCLC. The effect of SNPs of glycolytic genes on survival of NSCLC may differ depending on tumor histology. Further studies are needed to confirm our findings and to understand the role of glycolysis in determining prognosis in lung cancer.

Clinical trial identification

N/A

Legal entity responsible for the study

Kyungpook National University

Funding

Ministry of Science, ICT and Future Planning

Disclosure

All authors have declared no conflicts of interest.