Reducing ovarian failure during chemotherapy in early breast cancer: POEMS study

Speaker: Evandro de Azambuja

E. de Azambuja explains the study rationale, whether LHRH inhibition can reduce ovarian failure during chemotherapy in young women with early stage, hormone receptor negative breast cancer. Despite the challenge of low accrual, preserving the ovarian function led to better outcome.

Discussion Points

  • Which question was tested in the SOFT and the TEXT trials in young women with breast cancer?
  • How can study findings be interpreted?
  • Short summary of (topline) results of the POEMS study of prevention of early menopause in early, hormone receptor-negative breast cancer