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Anti-Cancer Agents & Biologic Therapy - Breast Cancer, Locally Advanced - Breast Cancer, Metastatic - Personalised Medicine

Adding Pertuzumab To First-Line Trastuzumab Plus AI ‘Effective’ For Advanced Breast Cancer

  • 20 Aug 2018
  • Author : By Shreeya Nanda, Senior medwireNews Reporter

The addition of pertuzumab to trastuzumab and an aromatase inhibitor shows promise for the first-line treatment of HER2- and hormone receptor-positive advanced breast cancer... 

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view detailsof Adding Pertuzumab To First-Line Trastuzumab Plus AI ‘Effective’ For Advanced Breast Cancer

Cancer Immunology and Immunotherapy - Imaging, Diagnosis and Staging - Translational Research

Radiomic Signature Predicts Response To PD-1 Pathway Blockade

  • 17 Aug 2018
  • Author : By Shreeya Nanda, Senior medwireNews Reporter

An imaging-based biomarker shows potential for personalising immunotherapy for advanced solid tumours...

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view detailsof Radiomic Signature Predicts Response To PD-1 Pathway Blockade

Anti-Cancer Agents & Biologic Therapy - Breast Cancer, Metastatic - Personalised Medicine

PFS Boost With Talazoparib In BRCA Mutation-Positive Patients With Advanced Breast Cancer

  • 16 Aug 2018
  • Author : By Shreeya Nanda, Senior medwireNews Reporter

Phase III trial results support the use of talazoparib in locally advanced or metastatic breast cancer patients with a BRCA1/2 mutation...

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view detailsof PFS Boost With Talazoparib In BRCA Mutation-Positive Patients With Advanced Breast Cancer

Anti-Cancer Agents & Biologic Therapy - Oesophageal Cancer - Surgery and/or Radiotherapy of Cancer

Neoadjuvant Chemoradiotherapy Survival Gain Demonstrated For Locally Advanced ESCC In China

  • 14 Aug 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Chinese patients undergoing surgery for locally advanced oesophageal squamous cell carcinoma may benefit from neoadjuvant chemoradiation...

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view detailsof Neoadjuvant Chemoradiotherapy Survival Gain Demonstrated For Locally Advanced ESCC In China

Breast Cancer, Early Stage - Surgery and/or Radiotherapy of Cancer

Adjuvant Radiotherapy Linked To Small Improvement In DCIS Patient Survival

  • 13 Aug 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

The addition of radiation to lumpectomy appears to offer a small reduction in breast cancer-related mortality for ductal carcinoma in situ patients, perhaps via a systemic effect...

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view detailsof Adjuvant Radiotherapy Linked To Small Improvement In DCIS Patient Survival

Anti-Cancer Agents & Biologic Therapy - Melanoma and other Skin Tumours - Personalised Medicine

BRIM Trials Analysis Identifies BRAF-Mutated Metastatic Melanoma Survival Predictors

  • 09 Aug 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

The outcome of patients using BRAF and/or MEK inhibitors for metastatic melanoma is predicted by four different clinical and tumour-related biomarkers...

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view detailsof BRIM Trials Analysis Identifies BRAF-Mutated Metastatic Melanoma Survival Predictors

Anti-Cancer Agents & Biologic Therapy - Non-Small-Cell Lung Cancer, Metastatic - Personalised Medicine

T790M Mutation Patterns Reported For Osimertinib-Resistant NSCLC Patients

  • 07 Aug 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Patients who progress while using osimertinib may or may not retain the epidermal growth factor receptor T790M sensitivity mutation...

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view detailsof T790M Mutation Patterns Reported For Osimertinib-Resistant NSCLC Patients

Anti-Cancer Agents & Biologic Therapy - Breast Cancer, Early Stage

Adjuvant Bevacizumab Offers No Extra Survival Benefit For HER2-Negative Breast Cancer

  • 27 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Adding bevacizumab to adjuvant chemotherapy does not boost invasive disease-free or overall survival for women with HER2-negative breast cancer at high risk of systemic recurrence...

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view detailsof Adjuvant Bevacizumab Offers No Extra Survival Benefit For HER2-Negative Breast Cancer

Breast Cancer, Early Stage - Complications of Treatment - Translational Research - Surgery and/or Radiotherapy of Cancer

TGFB1 Allele Predicts Fibrosis Risk After Breast Irradiation

  • 26 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

A single nucleotide polymorphism in transforming growth factor B1 may help identify early-stage breast cancer patients at risk of radiation-induced fibrosis...

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view detailsof TGFB1 Allele Predicts Fibrosis Risk After Breast Irradiation

Colon Cancer - Rectal Cancer - Surgery and/or Radiotherapy of Cancer

Laparoscopy For CRC Liver Metastases Surgery Increasingly Feasible

  • 25 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Around 70% of patients with colorectal cancer metastases in the liver may now be suitable for minimally invasive procedures, with this proportion expected to rise...

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view detailsof Laparoscopy For CRC Liver Metastases Surgery Increasingly Feasible

Cancer Immunology and Immunotherapy - Renal Cell Cancer - Melanoma and other Skin Tumours - Complications of Treatment

Diverse Delayed Skin Reactions To PD-1 Inhibitor Therapy Revealed

  • 24 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Cutaneous adverse reactions have reported in metastatic cancer patients who have used PD-1 inhibitors for at least 3 months...

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view detailsof Diverse Delayed Skin Reactions To PD-1 Inhibitor Therapy Revealed

Breast Cancer, Early Stage - Colon Cancer - Rectal Cancer - Prostate Cancer - Non-Small-Cell Lung Cancer, Early Stage - Patient Education

Complementary Medicine Use Linked to Conventional Cancer Treatment Refusal

  • 23 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

The relationship between complementary and conventional cancer treatments and its impact on survival is uncovered...

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view detailsof Complementary Medicine Use Linked to Conventional Cancer Treatment Refusal

Cancer Aetiology, Epidemiology, Prevention - Germ Cell Tumours - Complications of Treatment

Second Primary Tumour Risk Highlighted For Testicular Cancer Survivors

  • 20 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Men who receive platinum-based chemotherapy or radiation for testicular germ cell cancer are at increased risk of developing subsequent solid tumours...

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view detailsof Second Primary Tumour Risk Highlighted For Testicular Cancer Survivors

Anti-Cancer Agents & Biologic Therapy - Ovarian Cancer

Ovarian Cancer Patient QoL Preserved During Maintenance PARP Inhibitor Use

  • 19 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Long-term PARP inhibitor use does not adversely impact quality of life in patients with recurrent platinum-sensitive ovarian cancer patients compared with placebo...

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view detailsof Ovarian Cancer Patient QoL Preserved During Maintenance PARP Inhibitor Use

Breast Cancer, Early Stage - Surgery and/or Radiotherapy of Cancer

hsCRP Rise After Breast Cancer Radiation Predicts Severe Skin Toxicity

  • 18 Jul 2018
  • Author : By Lynda Williams, Senior medwireNews Reporter

Obesity and an increase in high-sensitivity C-reactive protein are both independently linked to early skin reactions in breast cancer patients undergoing radiotherapy...

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view detailsof hsCRP Rise After Breast Cancer Radiation Predicts Severe Skin Toxicity