ESMO Clinical Practice Guidelines: Hereditary Syndromes

The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine.

Latest enhanced and revised set of guidelines

Hereditary cancer syndromes are genetic disorders in which inherited genetic mutations increase the risk of the development of certain cancers including early onset of these cancers. Common examples of inherited cancer syndromes are hereditary breast and ovarian cancer syndrome and hereditary non-polyposis colon cancer or Lynch syndrome. This section currently includes guidelines that focus on cancer prevention and screening among individuals known to harbour a pathogenic BRCA1/2 mutation. The presence of a BRCA1 or BRCA2 mutation accounts for the majority of hereditary breast and ovarian cancer syndromes.

ESMO has Clinical Practice Guidelines on the following Hereditary Syndromes: Prevention and Screening in BRCA Mutation Carriers and Other Breast/Ovarian Hereditary Cancer Syndromes. They include information on incidence, diagnosis, staging and risk assessment, treatment and response evaluation and follow-up.