1464P - The difference in the serum levels of BDNF, IL-6, IL-8, IL-10 and EGF in oncology patients divided according to the presence of symptoms of depression

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Psychosocial Aspects of Cancer
Translational Research
Presenter Lubos Holubec
Authors L. Holubec1, O. Fiala2, V.M. Matejka2, J. Podlipny3, J. Dreslerova2, J. Vrzalova4, O. Topolcan4, J. Finek2, T. Svoboda2
  • 1Dept. Of Oncology & Radiotherapy, University Hospital Pislen, 30460 - Plzen/CZ
  • 2Department Of Oncology&radiotherapy, University Hospital Pilsen, 30460 - Pilsen/CZ
  • 3Department Of Psychiatry, University Hospital Pilsen, Czech Republic, 30460 - Pilsen/CZ
  • 4Department Of Nuclear Medicine, University Hospital Pilsen, 30599 - Pilsen/CZ

Abstract

Objective

To assess the differences in the serum levels of Brain-derived neurotrophic factor (BDNF), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and epidermal growth factor (EGF) in oncology patients with symptoms of depression and in oncology patients without symptoms of depression.

Methods

We administered the following self – report questionnaires to the hospitalized oncology patients (n = 32): Zung´s Self-Rating Depression Scale (ZSDS) and Symptom Check List Psychiatric Rating Scale (SCL 90). We also collected blood samples from these patients for the detection of the following factors: BDNF, IL-6, IL-8, IL-10 and EGF. The procedures had been fully explained to all patients and written informed consent had been obtained. The patients were divided into two groups according to the scores in ZSDS: a group with the presence of symptoms of depression (n = 20) and a group without the symptoms of depression (n = 12). The differences in the levels of BDNF, interleukins and EGF between the groups were statistically assessed by Wilcoxon rank-sum test.

Results

Oncology patients with the symptoms of depression showed significantly lower levels of BDNF (medians 1452.3 vs 3229.0 pg/ml, p = 0.014). There were no significant differences in the levels of IL-6, IL-8, IL-10 and EGF between the groups.

Conclusion

This result supports the hypothesis of diminished neuroplasticity in oncology patients with the symptoms of depression as measured by the serum levels of BDNF. This study was supported by research project MSM 0021620819.

Disclosure

All authors have declared no conflicts of interest.