54P - Telomere length, telomerase activity and DAPK1 expression, new markers for prognosis in non-small cell lung cancer
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Topics|| Lung and other Thoracic Tumours
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
T. Fernández1, I. Pascua1, C. de Juan1, J. Head1, A. Gómez2, J.R. Jarabo2, E. Fernández3, M. Benito4, P. Iniesta1, F. Hernando2
The essential role that telomeres and telomerase play in cancer makes them an important objective in the field of molecular oncology. Our aim in this work consists of analysing the prognostic role of telomere length and telomerase activity in non-small cell lung cancers (NSCLCs). Moreover, considering previous results and its potential as an important downstream target of Src kinase inhibitors (bosutinib, dasatinib), we evaluated the expression of death-associated protein kinase 1 (DAPK1), in relation to telomere status.  Oncology 82, (2012).  FEBS Journal 277, (2010).