127O - Programmed cell death 1 ligand 1 expression and association with survival in mesothelioma
|Date||27 March 2014|
|Session||Proffered Papers 2 - Tumour biology and translational research|
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
A.S. Mansfield1, T. Peikert2, A. Roden3, C. Krco4, S. Harrington5, H. Dong5, E. Kwon5
Due to the role Programmed Cell Death 1 Ligand 1 (PD-L1, aka B7-H1) has in establishing immune tolerance, its associations with worse survival in patients with many human malignancies, and the availability of agents to target PD-1:PD-L1 interactions, we decided to investigate the expression of PD-L1 in mesothelioma with the goal of exploring whether it might serve as a therapeutic target.