716P - Predictive role of neutrophil/lymphocyte ratio (NLR) for oxaliplatin efficacy in metastatic pancreatic cancer patients (pts)

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anti-Cancer Agents & Biologic Therapy
Pancreatic Cancer
Translational Research
Presenter Vincenzo Formica
Citation Annals of Oncology (2014) 25 (suppl_4): iv210-iv253. 10.1093/annonc/mdu334
Authors V. Formica1, C. Morelli1, P. Ferroni2, A. Nardecchia1, M. Tesauro3, V. Cereda1, F. Guadagni2, M. Roselli1
  • 1Medical Oncology Unit, Internal Medicine Department, 'Tor Vergata' University Hospital, 00133 - Rome/IT
  • 2Department Of Advanced Biotechnologies And Bioimaging, IRCCS San Raffaele Pisana, 00163 - Rome/IT
  • 3Internal Medicine Department, 'Tor Vergata' University Hospital, 00133 - Rome/IT

Abstract

Aim

To investigate the prognostic and predictive value of the inflammatory index Neutrophil/Lymphocyte ratio (NLR) in two homogeneous groups of chemotherapy-naïve metastatic pancreatic adenocarcinoma (PA) pts treated with either gemcitabine (GEM) or GEM + oxaliplatin (GEMOXA).

Methods

Consecutive PA pts (n = 103, male:female = 53:50) treated at a single center with either GEM (n = 45) or GEMOXA (n = 58), mainly according to patient preference or pre-existent diabetic neuropathy, were included between April'08- October'12. Exclusion criteria were treatment with steroids or active infection. NLR was assessed before and during therapy and correlated with outcome together with common clinical and biochemical variables.

Results

Among 17 analyzed variables NLR, Karhofsky Perfomance Status (KPS), d-dimer and erythrocyte sedimentation rate were found to be significantly associated with median Overall Survival (mOS) at the univariate analysis. Only NLR and KPS were independent prognosticator at multivariate analysis, with NLR displaying the highest statistical significance (Exp(b) = 1.09, p 0.01, meaning 9% increase in the risk of death for 1-unit increase in NLR). GEMOXA was associated with longer mOS, but this was not statistically significant (8 v 5.8 months (mo), p 0.07). NLR was also predictive of oxaliplatin activity, as only pts with NLR > 2.5 (cutoff determined upon ROC analysis) derived benefit from GEMOXA over GEM (mOS 9.7 v 3.9 mo, respectively, in pts with NLR > 2.5, p 0.005 and 11.7 vs 11.8 mo, respectively, in pts with NLR <2.5, p 0.26). Stable or decreasing NLR during therapy was associated with higher disease control rate (50% v 28%, p 0.02) and pts with baseline NLR > 2.5 who reported a NLR < 2.5 after one month of therapy had improved mOS as compared to pts with persistent NLR>2.5 (7.7 v 5.0 mo, p 0.003).

Conclusions

We were able to confirm the independent prognostic value of NLR for metastatic PA pts treated with gemcitabine-based first-line chemotherapy. NLR had also a predictive value in that only pts with high NLR (worse outcome) seem to benefit from the addition of oxaliplatin. NLR and KPS may help select pts for whom a particularly poor prognosis might justify more intensive, yet less tolerable, combination regimens.

Disclosure

All authors have declared no conflicts of interest.