129P - GAS5 long non coding RNA in malignant pleural mesothelioma

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Mesothelioma
Translational Research
Presenter Arun Renganathan
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors A. Renganathan1, J. Kresoja1, N. Echeverry1, G. Ziltener1, B. Vrugt2, I. Opitz3, R.A. Stahel4, E. Felley-Bosco1
  • 1Laboratory Of Molecular Oncology, University Hospital of Zurich, 8044 - Zurich/CH
  • 2Institute Of Surgical Pathology, University Hospital of Zurich, 8091 - Zurich/CH
  • 3Division Of Thoracic Surgery, University Hospital of Zurich, 8091 - Zurich/CH
  • 4Clinik And Policlinic Of Oncology, Universitätsspital Zürich, Zurich/CH

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive cancer with short overall survival. Long noncoding RNAs (lncRNA) are a class of RNAs more than 200 nucleotides that do not code for protein and are part of the 90% of the human genome that is transcribed yet less well characterized. Earlier experimental studies showed GAS5 (growth arrest specific transcript 5) lncRNA deletion in asbestos driven mesothelioma. The function of GAS5 is not well known, but it has been shown to act as glucocorticoid receptor decoy and microRNA “sponge”. Thus our aim is to investigate the possible role of the GAS5 in the growth of MPM.