129P - GAS5 long non coding RNA in malignant pleural mesothelioma
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
A. Renganathan1, J. Kresoja1, N. Echeverry1, G. Ziltener1, B. Vrugt2, I. Opitz3, R.A. Stahel4, E. Felley-Bosco1
Malignant pleural mesothelioma (MPM) is an aggressive cancer with short overall survival. Long noncoding RNAs (lncRNA) are a class of RNAs more than 200 nucleotides that do not code for protein and are part of the 90% of the human genome that is transcribed yet less well characterized. Earlier experimental studies showed GAS5 (growth arrest specific transcript 5) lncRNA deletion in asbestos driven mesothelioma. The function of GAS5 is not well known, but it has been shown to act as glucocorticoid receptor decoy and microRNA “sponge”. Thus our aim is to investigate the possible role of the GAS5 in the growth of MPM.