47P - Ethnic differences in copper transporter CTR1 expression and tissue platinum concentration in NSCLC
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Topics|| Lung and other Thoracic Tumours
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
E.S. Kim1, X. Tang2, C. Chow3, J. Fujimoto4, N. Kalhor3, S.G. Swisher5, D.J. Stewart6, I. Wistuba2, Z.H. Siddik7
African Americans (AAs) have lower lung cancer survival rates compared to Caucasian Americans (CAs). A recent study using ethnically-defined lymphoblastoid cell lines demonstrated that CAs were significantly more sensitive to cisplatin compared with AAs. Furthermore, African-American ethnicity was independently prognostic of poor tumor response to cisplatin in patients with advanced cervical cancer. We previously demonstrated that low tissue platinum (Pt) concentration and undetectable CTR1 (a Pt uptake transporter) level in NSCLC tumor specimens were significantly associated with reduced tumor response following Pt-based therapy. We hypothesized that NSCLC specimens from CAs would have higher CTR1 expression level and intratumoral Pt concentrations.