752 - Clinicopathologic significance of expression of nuclear factor kappa b and vascular endothelial growth factor in gastric cancer patients

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Gastric Cancer
Translational Research
Presenter Hyuk-Chan Kwon
Authors H. Kwon1, K.W. Park2, S. Kim3
  • 1Internal Medicine, Dong-A University Medical Center, 602-715 - Busan/KR
  • 2Internal Medicine, Dankook University, Cheonan/KR
  • 3Pathology, Dong-A University Medical Center, Busan/KR



Nuclear factor-?B (NF-?B) and vascular endothelial growth factor (VEGF) are involved in cell proliferation, invasion, angiogenesis and metastases. The principal objective of this study was to assess the prognostic significance of NF-?B and VEGF expression in gastric cancer.


The tumor tissues of 154 patients with gastric cancer, all of whom underwent potentially curative resection, were immunohistochemically evaluated using monoclonal antibodies against NF-?B and VEGF.


Positivity rates of NF-?B and VEGF were 44.2% and 39.6%, respectively. NF-?B expression in tumor tissues was correlated significantly with VEGF expression (p < 0.001). VEGF expression was related to Lauren's classification (p = 0.002), differentiation (p = 0.043), depth of invasion (p = 0.005), carcinoembryonic antigen (p = 0.032), and stage (p = 0.026). However, NF-?B expression was not related to any of these parameters. Univariate analysis demonstrated that NF-?B expression was significantly related with both 5-year disease free survival (65.2% vs. 46.4%, p = 0.007), and 5-year overall survival (60.0% vs. 42.5%, p = 0.014). Multivariate analysis verified that NF-?B was independently associated with disease free survival (hazard ratio: 2.082, p = 0.005), and overall survival (hazard ratio: 1.841, p = 0.008). However, VEGF did not appear to be related to adverse clinical outcome.


NF-?B expression in tumor tissue is associated with poor survival in gastric cancer patients.


All authors have declared no conflicts of interest.