752 - Clinicopathologic significance of expression of nuclear factor kappa b and vascular endothelial growth factor in gastric cancer patients

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Gastric Cancer
Translational Research
Presenter Hyuk-Chan Kwon
Authors H. Kwon1, K.W. Park2, S. Kim3
  • 1Internal Medicine, Dong-A University Medical Center, 602-715 - Busan/KR
  • 2Internal Medicine, Dankook University, Cheonan/KR
  • 3Pathology, Dong-A University Medical Center, Busan/KR

Abstract

Aim

Nuclear factor-?B (NF-?B) and vascular endothelial growth factor (VEGF) are involved in cell proliferation, invasion, angiogenesis and metastases. The principal objective of this study was to assess the prognostic significance of NF-?B and VEGF expression in gastric cancer.

Methods

The tumor tissues of 154 patients with gastric cancer, all of whom underwent potentially curative resection, were immunohistochemically evaluated using monoclonal antibodies against NF-?B and VEGF.

Results

Positivity rates of NF-?B and VEGF were 44.2% and 39.6%, respectively. NF-?B expression in tumor tissues was correlated significantly with VEGF expression (p < 0.001). VEGF expression was related to Lauren's classification (p = 0.002), differentiation (p = 0.043), depth of invasion (p = 0.005), carcinoembryonic antigen (p = 0.032), and stage (p = 0.026). However, NF-?B expression was not related to any of these parameters. Univariate analysis demonstrated that NF-?B expression was significantly related with both 5-year disease free survival (65.2% vs. 46.4%, p = 0.007), and 5-year overall survival (60.0% vs. 42.5%, p = 0.014). Multivariate analysis verified that NF-?B was independently associated with disease free survival (hazard ratio: 2.082, p = 0.005), and overall survival (hazard ratio: 1.841, p = 0.008). However, VEGF did not appear to be related to adverse clinical outcome.

Conclusion

NF-?B expression in tumor tissue is associated with poor survival in gastric cancer patients.

Disclosure

All authors have declared no conflicts of interest.