41P - Circulating tumor cells as predictor of response to platinum and pemetrexed chemotherapy in patients with advanced adenocarcinoma of the lung - an u...

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Non-Small-Cell Lung Cancer, Metastatic
Translational Research
Presenter Francesco Grossi
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors F. Grossi1, E. Rijavec1, G. Barletta1, C. Sini1, A. Truini1, A. Alama1, M.G. Dal Bello1, S. Coco1, M. Truini2, C. Genova1
  • 1Lung Cancer Unit, IRCCS AOU San Martino IST - Istituto Nazionale per la Ricerca sul Cancro, 16132 - Genova/IT
  • 2Department Of Pathology, IRCCS AOU San Martino IST - Istituto Nazionale per la Ricerca sul Cancro, 16132 - Genova/IT

Abstract

Background: Circulating Tumor Cells (CTC) are cells spread from the primary tumor into the bloodstream; CTC are involved in the development of distant metastases and are associated with aggressive disease.The aim of this study is to evaluate the correlation between the numeric variation of CTC in the blood of patients (pts) with advanced adenocarcinoma (ADK) of the lung during chemotherapy (CHT) and the radiological response to explore their potential role as early predictor of treatment response.