P-0196 - AQP1 expression predicts survival in patients with colon cancer

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Colon Cancer
Translational Research
Presenter Woog Kang Byung
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors S. Yoon Ghil
  • Kyungpook National University Hospital, Daegu/KR

Abstract

Introduction

We analyzed the prognostic impact of aquaporin 1 (AQP1), aquaporin 3 (AQP3), and aquaporin 5 (AQP5) expression in a large number of patients with colon cancer.

Methods

AQP1, AQP3, and AQP5 expression were investigated on the basis of the immunohistochemistry of tissue microarray specimens from 486 colon cancer patients who underwent curative surgery between 2006 and 2010. We scored the staining intensity (0 through 3) and percentage of positive cells (0 through 4), and the staining score was defined as sum of these scores used to categorize the AQP expression as negative (0 through 2), weak (3 through 5), or strong (6 or more).

Results

For the 486 patients, the median age was 66 (30-90) years at the time of surgery. The pathologic stages after the surgical resection were as follows: stage I (n = 98), stage II (n = 213), and stage III (n = 175). A total of 298 (61.3%) were identified as AQP1-positive (staining score >6). AQP3 and AQP5 overexpressed in 56 (11.5%) and 145 (29.8%) of the cohort, respectively. AQP1 overexpression was closely correlated with patient' overall survival (OS; p = 0.002) and disease-free survival (DFS; p = 0.026). Moreover, a multivariate analysis revealed that AQP1 overexpression was an independent prognostic marker of survival for the colon cancer patients. However, no significant association was observed between AQP3 and AQP5, and survival in a multivariate analysis.

Conclusion

AQP1 expression in tumor tissue can be considered a prognostic marker in patients with colon cancer after curative surgery.