874TiP - ANZUP 1302 P3BEP companion translational study: Prospective collection of whole blood, serum, plasma and tumour tissue in a randomized trial of che...

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Germ Cell Tumours
Translational Research
Presenter Peter Grimison
Citation Annals of Oncology (2014) 25 (suppl_4): iv280-iv304. 10.1093/annonc/mdu337
Authors P. Grimison1, M. Stockler2, S. Yip3, G. Toner4, L. Horvath1
  • 1Medical Oncology, Chris O'Brien Lifehouse, 2050 - Sydney/AU
  • 2Nhmrc Clinical Trials Centre, University of Sydney, Sydney/AU
  • 3Nhmrc Clinical Trials Centre, University of Sydney, 2050 - Sydney/AU
  • 4Medical Oncology, Peter MacCallum Cancer Centre, Melbourne/AU

Abstract

Background

The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) is conducting a randomized trial of accelerated versus standard BEP chemotherapy for intermediate and poor risk metastatic GCTs. This translational substudy will prospectively collect blood and GCT tissue in a centralized biobank. Overall aim: To identify pharmacogenomic and molecular markers of treatment failure, toxicity and overall survival in metastatic GCTs. This could lead to the design of tailored treatments, for example incorporating a higher dose of or an alternative form of chemotherapy.

Trial design

Specific objectives: 1. Consent ≤ 500 individuals in our trial for donation of blood and cancer tissue samples for future genomic analyses 2. Collect, process and freeze participant blood (50mL) as whole blood, plasma and serum pre-chemotherapy 3. Collect a representative formalin fixed paraffin embedded (FFPE) block of participant tumour tissue 4. Transport blood and cancer tissue samples to the Chris O'Brien Lifehouse cryostorage facility in Sydney, Australia 5. Establishment of a national biobank for testicular cancer Planned future objectives: Study association of progression (relapse or refractory disease), overall survival and toxicity (as surrogates for excess drug exposure) with genetic polymorphisms known to be involved in: - bleomycin metabolism: BLMH (bleomycin hydrolase gene) variant A1450G SNP - etoposide metabolism and transport: ABCB1 (3435T variant), CYP3A5 - candidate tumour-related markers including DNA methylation profiles of cancer-related genes Conclusions: The ultimate goal of this research is to facilitate a “personalised medicine” approach to the treatment of individuals with advanced germ cell tumours (GCT), with the ultimate goal of curing 100% of patients. We invite researchers with blood or tumour samples, and/or expertise in relevant laboratory techniques to collaborate in future analyses. Email: p3BEP@ctc.usyd.edu.au website:http://www.anzup.org.au

Disclosure

All authors have declared no conflicts of interest.