62O - Thirty and 90-day mortality after lung cancer resection in 2242 patients

Date 16 April 2015
Event ELCC 2015
Session Medical and surgical oncology
Topics Non-Small-Cell Lung Cancer, Early Stage
Surgery and/or Radiotherapy of Cancer
Presenter Anna Frick
Citation Annals of Oncology (2015) 26 (suppl_1): 18-23. 10.1093/annonc/mdv048
Authors A.E. Frick1, H. Lüders2, G. Leschber1
  • 1Department Of Thoracic Surgery, Evangelische Lungenklinik ELK Berlin Chest Hospital, 13125 - Berlin/DE
  • 2Department Of Thoracic Surgery, Evangelische Lungenklinik ELK Berlin Chest Hospital, 13125 Berlin - Berlin/DE

Abstract

Aim/Background

Operations for lung cancer in specialized centers are associated with low 30-day mortality. However, recent publications indicated that mortality rates at 90-days probably provide a better estimation of the operative risk. The purpose of this retrospective single center study was to evaluate the 30- and 90-day mortality of patients after lung cancer resection in a certified lung cancer center.

Methods

All patients undergoing lung cancer resection from September 1998 to December 2013 were included (segmentectomy, lobectomy, sleeve lobectomy, pneumonectomy or extended resections). Univariate and multivariate methods for logistic regression model were used to analyze mortality.

Results

Out of 2242 pulmonary cancer resections, segmentectomy was performed in 106, lobectomy in 1638, sleeve lobectomy in 312, pneumonectomy in 43 and extended pneumonectomy in 143 patients. Overall 30-day mortality rate was 1.5% (34 patients) and 90-day mortality rate was 3.4% (76 patients). For segmentectomy 30-day and 90-day mortality rates were 0% and 1.9% (2 pat.), respectively. In patients who received lobectomy 30-day and 90-day mortality rate were 1.2% (20 pat.) and 2.9% (48 pat.), respectively. For sleeve lobectomy 30-day and 90-day mortality rate were 2.5% (8 pat.) and 4.8% (15 pat.), respectively. For pneumonectomy 30-day and 90-day mortality rate were 0% and 2.3% (1 pat.), respectively. In patients who underwent extended pneumonectomy 30-day and 90-day mortality rate were 4.2% (6 pat.) and 7% (10 pat.), respectively.

Conclusions

Although our results show a very low overall mortality, the observed 90-day mortality is tripled compared to 30-day mortality after major pulmonary resection. Higher operative risks are shown in patients with extended resections therefore thorough preoperative work-up of cardiopulmonary function should be performed for good risk assessment.

Disclosure

All authors have declared no conflicts of interest.