1008 - The role of function- sparing surgeries in patients with invasive locally advanced cervical cancer

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Cervical Cancer
Surgery and/or Radiotherapy of Cancer
Presenter Visola Navruzova
Authors V. Navruzova1, S. Navruzov2
  • 1Oncogynaecology, National Cancer Center of Uzbekistan, 100174 - Tashkent/UZ
  • 2Administration, National Cancer Center of Uzbekistan, UZ-100174 - Tashkent/UZ

Abstract

Background

The incidence rate among young women leads to the necessity of the development of new methods and improvement of used surgical, combined and complex treatment for patients with locally spread cervical cancer (LACC).As a result of large radical operations, different complications which quite often result in “qualitative characteristic of life” (physical, functional, psychological and social) with feasible disability of women are possible. Surgical deprivation of ovarian function leads to a sharp fall-off of the level of sex hormones (first of all, estradiol) in blood. Patients with bilateral salpingo-oophorectomy, particularly at young age, have long-term effects of estrogen deficit of more severe character than women with natural menopause. For patients with invasive and LACC ovarian transposition the function- sparing surgery is the option in order to exteriorize them from supposed fields of radiation in patients with invasive and locally advanced cervical cancer.

Material and methods

156 patients with LACC received complex treatment that included surgery expansion of extended uterectomy with ovarian transposition at National Oncological Research Centre of MH of RUz over 2008-2012 yy. Patients aged from 23 to 45 yrs. Follow–up period were from 1 month till 3 years. Reproductive age patients with ovarian transposition had the level of sex hormones in blood according to normal in 94,7% cases after conducted surgery. Estradiol level in patients’ blood was up to143,6 ng/ml (normal -phase 77-277 ng/ml) in preoperative period.This rate being up to 140 ng/ml after surgery. After radiotherapy these patients' rate of estradiol level in blood made up to139 ng/ml. This showed that ovarian function (gonads) is retained for 80 % of patients after performing of radiotherapy.

Conclusions

Our study results showed that the conduction of organ-preserving exposure allows not only to cure the malignant process at early stages of its advance without lowering of therapy effect but also to preserve the important functions of woman body that promote full-fledged medical and social rehabilitation of patients.

Disclosure

All authors have declared no conflicts of interest.