827P - Renal metastases to pancreas: do not operate all and always?

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Renal Cell Cancer
Surgery and/or Radiotherapy of Cancer
Presenter Luciano Burattini
Citation Annals of Oncology (2014) 25 (suppl_4): iv280-iv304. 10.1093/annonc/mdu337
Authors L. Burattini1, M. Santoni1, C. Porta2, C.N. Sternberg3, G. Procopio4, U. Basso5, U. De Giorgi6, M. Rizzo7, C. Ortega8, F. Massari9, C. Masini10, M. Milella11, G. Di Lorenzo12, L. Cerbone13, A. Conti14, S. Buti15, S. Partelli16, M. Falconi16, D. Santini17, S. Cascinu1
  • 1Clinica Di Oncologia Medica, AOU Ospedali Riuniti Ancona Università Politecnica delle Marche, 60126 - Ancona/IT
  • 2Oncologia Medica, Ospedale San Matteo, IT-27100 - Pavia/IT
  • 3Medical Oncology, San Camillo Forlanini Hospital, Rome/IT
  • 4Oncologia Medica, Fondazione IRCCS - Istituto Nazionale dei Tumori, 20133 - Milano/IT
  • 5Medical Oncology, IOV-IRCCS, 35138 - Padova/IT
  • 6Medical Oncology, Istituto Tumori della Romagna I.R.S.T., 47014 - Meldola/IT
  • 7Medical Oncology, Azienda Ospedaliera Antonio Cardarelli, Naples/IT
  • 8Oncologia Medica 1, IRCC - Fondazione Piemontese per la Ricerca sul Cancro Onlus, Candiolo/IT
  • 9Oncologia Medica, Azienda Ospedaliera Universitaria Integrata Verona-"Borgo Roma", 37134 - Verona/IT
  • 10Dept. Of Hematology/oncology, Ospedale Policlinico-Modena, 41214 - Modena/IT
  • 11Divisione Di Oncologia Medica A, Istituto Regina Elena, 00144 - Roma/IT
  • 12Genitourinary Cancer Section And Rare-cancer Center, University Federico II, 80131 - Napoli/IT
  • 13Medical Oncology, San Camillo and Forlanini Hospital, Rome/IT
  • 14Clinica Di Oncologia Medica, AO Ospedali Riuniti, Università Politecnica delle Marche, Ancona/IT
  • 15Oncologia, Azienda Ospedaliero-Universitaria di Parma, 43126 - Parma/IT
  • 16Division Of Pancreatic And Digestive Surgery, AOU Ospedali Riuniti Ancona Università Politecnica delle Marche, 60126 - Ancona/IT
  • 17Medical Oncology, university campus bio-medico, 00128 - rome/IT

Abstract

Aim

Methods

Data from 19 Italian centers involved in the treatment of metastatic RCC were retrospectively collected. Kaplan-Meier and log-rank test methods were used to evaluate the overall survival (OS). Clinical variables considered were sex, age, concomitant metastasis to other sites, surgical resection of PM-RCC and time to PM-RCC occurrence. A subsequent univariate and backward multivariate Cox regression model was fitted to the data to correct for the effect of covariates.

Results

103 patients were enrolled in the analysis; 66 of them were males. Median age was 67 yrs (range 43–85 yrs). PM-RCC were synchronous in only 3 patients (3%). In 56 patients (54%), the pancreas was the only metastatic site, whereas in the other 47 patients lung (57%), lymph nodes (28%) and liver (21%) were the most common concomitant metastatic sites. Median time for PM-RCC occurrence was 9.6 yrs (range 0–24 yrs) after nephrectomy. Surgical resection of PM-RCC was performed in 40 patients (39%) and consisted of total (21%), distal (71%) or central pancreatectomy (8%). Median OS was not reached in patients who underwent surgical resection of PM-RCC and 11.1 yrs in the unresected patients (p < 0.001). At univariate analysis, only the presence of concomitant metastases to other sites (p = 0.008) was significantly associated with a poor prognosis, whereas none of the evaluated variables were independent prognostic factors at multivariate analysis.

Conclusions

The presence of PM-RCC is associated with long survival, which is surprisingly not associated with surgical resection, time of PM-RCC occurrence and the presence of concomitant metastases to other sites, although these data should be confirmed in a larger population.

Disclosure

All authors have declared no conflicts of interest.