P-095 - Palliative radiotherapy for haemostasis in irresectable gastric cancer

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Gastric Cancer
Palliative Care
Surgery and/or Radiotherapy of Cancer
Presenter M. Ayad
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors M. Ayad1, N. Aksil2, K. Boualga3
  • 1EHS Centre Anti Cancer, Blida/DZ
  • 2Centre Anti Cancer, Blida/DZ
  • 3CAC, Blida/DZ

Abstract

Introduction

Bleeding is one of the symptoms of advanced gastric cancer. There are several treatment options for bleeding control, including palliative surgery, endoscopic intervention, vasoconstrictor injection and radiotherapy, but little research into which treatment is the most effective option has been performed. The purpose of this study is to evaluate the outcomes of patients with gastric cancer bleeding who had been treated with palliative radiotherapy with haemostatic intent.

Methods

34 gastric cancer patients aged 52 – 73 (median 68) with active bleeding or anaemia resulting from inoperable gastric cancer were treated with short course radiotherapy. Thirty-nine (75%) patients received single 8Gy fraction and 13 (25%) patients received 20Gy in 5 daily fractions. Responses to treatment were evaluated based on the overall survival, changes of hemoglobin level and number of transfusions received before and after radiotherapy.

Results

The overall median survival (calculated from last day of treatment to date of death) was 157 days (95% Cl 119 -189 days), making actuarial 12-month survival 15%. The need of transfusion was evaluable in 29 patients, and the response rate was 50%, with less need of blood transfusions within one month after radiotherapy. There was also an increment in mean hemoglobin level (0.66 ± 1.12 g/dL, p < 0.001) post radiotherapy in 30 evaluable patients.

Conclusion

Palliative short course radiotherapy is a reasonably effective treatment, which can provide durable local control to bleeding gastric cancer.