91P - Definitive concomitant radiochemotherapy (RCT) treatment for locally advanced (LA) non small cell lung cancer (NSCLC): Evaluation of hematological a...

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Non-Small-Cell Lung Cancer, Locally Advanced
Surgery and/or Radiotherapy of Cancer
Presenter Vieri Scotti
Citation Annals of Oncology (2015) 26 (suppl_1): 24-28. 10.1093/annonc/mdv049
Authors V. Scotti, D. Scartoni, I.F. Furfaro, G. Simontacchi, C. De Luca Cardillo, B. Agresti, C. Talamonti, L. Livi
  • Radiotherapy Oncology, Azienda Ospedaliera Universitaria Careggi, 50127 - Firenze/IT

Abstract

Aim/Background

To evaluate correlation between esophageal and hematological toxicity and chemotherapy (CT) in patients treated with concurrent RCT for LA NSCLC. We evaluate also dosimetric parameters of irradiated esophageal volume.

Methods

37 patients, 26 female and 11 male, with mean age of 62.3 years (range 43-75) were evaluated. CT schedules were Cisplatin-Vinorelbine (CDDP 75 mg/m2 d1-VNR 25 mg/m2 d1-8 q21) in 15 cases, Cisplatin-Docetaxel (CDDP 75 mg/m2 d1-TXT 75 mg/m2 d1 q21) in 22 cases. Histology was adenocarcinoma in 16 cases, squamous cells carcinoma in 21 cases. All patients received radiotherapy (RT) with radical dose (mean dose: 64 Gy, range 60-70 Gy). We evaluate acute esophageal and hematological toxicity according to Radiotherapy Oncology Group (RTOG) scales during treatment and for 3 months after the treatment end. We evaluate the impact of different treatment CT schedule in the development of esophageal toxicity. We also reviewed dosimetric parameters relative to irradiated esophageal volume and occurrence of toxicity.

Results

Twelve patients experienced grade 1-3 leukopenia; 2 patients experienced grade 2 or 3 and 10 patients experienced grade 1 to 2 anemia. Twenty-two patients experienced esophageal toxicity, with a maximum grade of 1. Only 2 patients needed interruption of RT because of esophagitis. No correlation was found between hematological toxicity or schedule of CT and esophageal toxicity. We found a correlation between irradiated esophageal volume and the occurrence of esophageal toxicity, according to literature results. In particular we found a statistically significant correlation between the increase of V20 (p: 0.036); V40 (p: 0.027) and V45 value (p: 0.024) and the occurrence of esophageal toxicity.

Conclusions

There is no significant correlation between CT, hematological and esophageal toxicity in patients treated with concurrent RCT for LA NSCLC. This confirm the safety and feasibility of these CT schedules in concomitant setting in LA NSCLC and the importance of respecting constraints for esophageal toxicity prevention.

Disclosure

All authors have declared no conflicts of interest.