1457P - Incidence, mortality and time trends of childhood soft tissue sarcomas in Russia

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Soft Tissue Sarcomas
Cancer Aetiology, Epidemiology, Prevention
Cancer in Special Situations
Presenter Maxim Rykov
Citation Annals of Oncology (2014) 25 (suppl_4): iv494-iv510. 10.1093/annonc/mdu354
Authors M. Rykov, T. Men
  • General Oncology, Institute of Pediatric Oncology and Hematology, 115478 - Moscow/RU

Abstract

Aim

To estimate patterns and trends of childhood soft tissue sarcomas (STS) in Russia with respect to incidence and mortality data.

Methods

The analysis was based on annual reports of Ministry of Health and Federal State Statistics Service on cases, deaths and person-years by gender, age, calendar year and region. Age-specific and age-adjusted rates were calculated. Additionally, the average annual percent change (AAPC) with 95% confidence interval (95% CI), derived from a Poisson regression model, was estimated. Excess or deficit of incidence rates for geographical areas were expressed as standardized incidence ratio (SIR; standardized to rate of Russia as whole).

Results

STS represent 5.8% of all childhood malignancies in Russia registered during for 2008-2012, behind leukaemias, brain tumors, lymphomas and renal tumors. The age-adjusted incidence rate (ASR, world standards) of STS per 1,000,000 patients below the age of 15 years was 7.2 (774 incident cases). The highest age-specific incidence was observed in children aged 0-4 years (11.5 per 1,000,000). A significant incidence trend was shown with AAPC of 3.7% [95% CI 3.2-4.2] between 1989 and 2012. The largest increase was observed in children aged 0-4 years (AAPC=5.6% [95% CI 4.7- 6.5]. There were doubling of average Russian incidence rates in some areas such as Samarskaya oblast (about 15 cases per 1,000,000, SIR=2 [95% CI 1.3-2.8]. STS accounts for 10.8% of deaths from cancer in children in Russia and thus ranks third behind leukaemia and brain tumors. The age-adjusted mortality rate of STS per 1,000,000 patients below the age of 15 years for 2008-2012 was 4.3 (459 deaths). The highest age-specific incidence was observed in children aged 1-4 years (6.7 per 1,000,000). A significant increase of mortality between 1999 and 2012 was shown with AAPC of 3.2% [95% CI 1.8- 4.7]). The geographical differences of death rates were not analysed because of small numbers.

Conclusions

Significant increase of both incidence and mortality for childhood STS were found in Russia for recent decades. Further study is required to explain higher rate areas.

Disclosure

All authors have declared no conflicts of interest.