89P - The impact of epidermal growth factor receptor (EGFR) mutation on central nervous system (CNS) invasion and survival in patients with surgically res...

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Non-Small-Cell Lung Cancer, Metastatic
Pathology/Molecular Biology
Presenter Takefumi Akita
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors T. Akita, T. Etou, Y. Shishido, S. Morita, K. Asada, M. Hirose, S. Ota, M. Fujii, T. Shirai
  • Pulmonary Division, Shizuoka-General-Hospital, 4208527 - Shizuoka/JP


CNS invasion is common in patients with non-small cell lung cancer (NSCLC) and associated with a poor outcome. For patients who have developed CNS invasion, those with epidermal growth factor (EGFR) mutation derive clinical benefit from EGFR tyrosine kinase inhibitors (TKIs). The clinical manifestation of CNS invasion, the EGFR mutation, and prognosis are unclear in patients with resected stage I to III lung adenocarcinoma. The aim of this study is to analyze the impact of EGFR gene mutation on CNS-recurrence and prognosis in patients with surgically resected lung adenocarcinoma.