18P - Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Lung and other Thoracic Tumours
Pathology/Molecular Biology
Presenter Hae Won Lee
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors H.W. Lee1, M.C. Kang1, J.H. Kwon1, D.W. Choe2, C.H. Kim3, H.J. Yoo4, J.S. Koh5, J.H. Park1
  • 1Thoracic Surgery, Korea Cancer Center Hospital, 139-706 - Seoul/KR
  • 2Radiology, Korea Cancer Center Hospital, 139-706 - Seoul/KR
  • 3Pulmonology, Korea Cancer Center Hospital, 139-706 - Seoul/KR
  • 4Radiation Oncology, Korea Cancer Center Hospital, 139-706 - Seoul/KR
  • 5Pathology, Korea Cancer Center Hospital, 139-706 - Seoul/KR

Abstract

Protein tyrosine kinase 7 (PTK7) is a catalytically inactive receptor tyrosine kinase that is also known as colon carcinoma kinase-4 (CCK-4). Recent reports have shown that PTK7 plays an important role in carcinogenesis, and it is known to be up-regulated in gastric cancer, colon cancer, esophageal cancer, and liposarcoma. However, we found that PTK7 expression was down-regulated at the mRNA as well as protein levels in human lung squamous cell carcinoma (LSCC), unlike in other tumors. In this study, we attempted to explore the role of PTK7 in lung cancer.