18P - Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Topics|| Lung and other Thoracic Tumours
|Presenter||Hae Won Lee|
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
H.W. Lee1, M.C. Kang1, J.H. Kwon1, D.W. Choe2, C.H. Kim3, H.J. Yoo4, J.S. Koh5, J.H. Park1
Protein tyrosine kinase 7 (PTK7) is a catalytically inactive receptor tyrosine kinase that is also known as colon carcinoma kinase-4 (CCK-4). Recent reports have shown that PTK7 plays an important role in carcinogenesis, and it is known to be up-regulated in gastric cancer, colon cancer, esophageal cancer, and liposarcoma. However, we found that PTK7 expression was down-regulated at the mRNA as well as protein levels in human lung squamous cell carcinoma (LSCC), unlike in other tumors. In this study, we attempted to explore the role of PTK7 in lung cancer.