1182PD - Prognostic factors in resected AIS, MIA and lepidic predominant lung adenocarcinoma

Date 27 September 2014
Event ESMO 2014
Session NSCLC early stage, SCLC and other thoracic malignancies
Topics Non-Small-Cell Lung Cancer, Early Stage
Pathology/Molecular Biology
Presenter Jung-Jyh Hung
Citation Annals of Oncology (2014) 25 (suppl_4): iv409-iv416. 10.1093/annonc/mdu347
Authors J. Hung1, T. Chou2, W. Hsu1, Y. Wu1
  • 1Department Of Surgery, Taipei Veterans General hosptal, 112 - Taipei/TW
  • 2Department Of Pathology, Taipei Veterans General hosptal, 112 - Taipei/TW

Abstract

Aim

The new International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS) lung adenocarcinoma classification has been proposed in 2011. The aim of the study is to demonstrate the prognostic factors and pattern of recurrence in AIS, MIA and lepidic predominant lung adenocarcinoma.

Methods

We retrospectively reviewed 545 patients undergoing surgical resection for lung adenocarcinoma in Taipei Veterans General Hospital between 2006 and 2010. Fifty-two patients with lepidic predominant lung adenocarcinoma were identified. The predictive factors and pattern of recurrence of these patients were investigated.

Results

The 5-year overall survival and recurrence-free rates were 84.0% and 83.0%, respectively. During follow-up, 7 (13.5%) patients developed recurrence. The median time to recurrence was 28.7 months (range, 10.6 to 57.8 months). The percentage of T2-4 (P = 0.003), N1-2 (P < 0.001), TNM stage II-III (P < 0.001), and visceral pleural invasion (P = 0.049) was significant higher in patients with recurrence. N status (N1-2 vs. N0) (P < 0.001), TNM stage (II-III vs. I) (P < 0.001) were significant prognostic factors of freedom from recurrence in univariate analysis. Visceral pleural invasion (P = 0.093) and presence of solid pattern (P = 0.089) tended to be significant prognostic factors of freedom from recurrence in univariate analysis. TNM stage (II-III vs. I) (P = 0.005) was still a significant predictive factor of freedom from recurrence in multivariate analysis.

Conclusions

The overall survival and freedom from recurrence rates were good in lepidic predominant adenocarcinoma. TNM stage (II-III vs. I) was a significant predictive factor of freedom from recurrence in these patients.

Disclosure

All authors have declared no conflicts of interest.