1181PD - Maximum standardized uptake values on positron emission tomography correlates with IASLC/ATS/ERS histologic subtypes and prognosis of clinical stag...

Date 27 September 2014
Event ESMO 2014
Session NSCLC early stage, SCLC and other thoracic malignancies
Topics Non-Small-Cell Lung Cancer, Early Stage
Imaging, Diagnosis and Staging
Pathology/Molecular Biology
Presenter Yoshihiro Miyata
Citation Annals of Oncology (2014) 25 (suppl_4): iv409-iv416. 10.1093/annonc/mdu347
Authors Y. Miyata1, T. Yoshiya1, T. Mimae2, S. Sasada3, N. Tsubokawa3, H. Nakayama4, M. Okada5
  • 1Surgical Oncology Dept., Hiroshima University, 734-8551 - Hiroshima/JP
  • 2Surgical Oncology, Hiroshima University, 7348551 - Hiroshima/JP
  • 3Surgical Oncology, Hiroshima University, 734-0037 - Hiroshima/JP
  • 4Thoracic Oncology, Kanagawa Cancer Center Hospital, Yokohama/JP
  • 5Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 734-8551 - Hiroshima/JP

Abstract

Aim

High maximum standardized uptake values (SUVmax) on [18F]-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) have been demonstrated to be associated with inferior survival in lung adenocarcinoma. In this study, we investigated the association between SUVmax and the IASLC/ATS/ERS histologic subtypes of clinical stage IA lung adenocarcinoma.

Methods

We retrospectively examined 347 consecutive patients with clinical stage IA lung adenocarcinoma who underwent complete resection. The percentage of each histological component was recorded. Patients were classified by the predominant histologic grade and solid/micropapillary (S/Mp) component ratio in the tumour.

Results

The mean (± SD) SUVmax of all patients was 2.31 ± 2.46. A total of 180 tumours (53%) had low-grade histology (38 adenocarcinoma in situ, 12 minimally invasive adenocarcinoma, and 130 lepidic predominant), 131 (38%) had intermediate-grade histology (70 papillary, 61 acinar predominant), and 36 (11%) had high-grade histology (30 solid, 6 Mp predominant). Thirty-nine (11%), 71 (20%), and 237 (68%) patients had high (>40%), intermediate (5-40%), and low (<5%) S/Mp ratios, respectively. High SUVmax was associated with high-grade histology (SUVmax: high, 5.0; intermediate, 2.2; low, 0.94; p < 0.001) and increased risk of recurrence (5-year disease-free survival: high, 67.7 %; intermediate, 81.4%; low, 100%; p < 0.001). Moreover, SUVmax significantly correlated with the S/Mp ratio in the tumour (SUVmax: high, 4.8; intermediate, 2.7; low, 1.1; p < 0.001) and the risk of recurrence (5-year disease-free survival: high, 68.4%, intermediate, 82.6%, low, 94.9%; p < 0.001). Multivariate analysis revealed that SUVmax was an independent predictor for S/Mp predominant subtypes (p = 0.021).

Conclusions

SUVmax on PET is strongly associated with histologic classification and S/Mp ratio in lung tumours. SUVmax and predominant subtypes, especially the S/Mp ratio, have strong biologic implications in clinical stage IA lung adenocarcinoma.

Disclosure

All authors have declared no conflicts of interest.