727P - Comparison in 1323 patients of preoperative imaging staging and pathological examination of resected pancreatic head adenocarcinoma: series of the A...

Date 30 September 2012
Event ESMO Congress 2012
Session Poster presentation II
Topics Pancreatic Cancer
Imaging, Diagnosis and Staging
Pathology/Molecular Biology
Presenter Marine Gilabert
Authors M. Gilabert1, J.M. Boher2, J.L. Raoul3, O. Turrini3, F. Paye4, P. Bachellier5, J. Delpero6, G. Afc7
  • 1Medical Oncology, Institut Paoli Calmettes, 13009 - Marseille CEDEX 9/FR
  • 2Bioinformatics, Institut Paoli-Calmettes, marseille/FR
  • 3Oncology, Institut Paoli-Calmettes, 13009 - Marseille/FR
  • 4Surgery, Hopital Saint Antoine, Paris/FR
  • 5Surgery, Hopital de Hautepierre, Strasbourg/FR
  • 6Surgical Oncology, Institut Paoli-Calmettes, Marseille/FR
  • 7France, Association francaise de chirurgie, France/FR

Abstract

Resection is possible in less than 15% of pancreatic ductal adenocarcinoma (PDAC) patients. Prognosis is dismal and particularly related to arterial, venous or lymph node invasion. In this retrospective analysis were compared imaging preoperative data and pathological reports on arterial, venous and lymph node invasion in a large series of PDAC benefiting from pancreaticoduodenectomy. Retrospective series of 1323 patients resected for a PDAC of the head of pancreas in 35 French and 2 Swiss centers, data analyzed by the Association Française de Chirurgie; 142 with (95 chemoradiotherapy, 47 chemotherapy; given to a borderline tumor in 65% and systematically in 35%) and 1181 without preoperative treatment. Preoperative imaging consisted in: ceCTscan (97%), ceMRI (45%), US (65%) and endoscopic US (59%). Were calculated concordance, Sensibility, Specificity, PPV and NPV of preoperative data compared to pathological conclusions. Artery-Artery + Vein-Vein+ LN- LN+ Imaging negative 1047 16 788 137 246 613 positive 17 9 40 130 38 157 Concordance 97% 84% 38% Se 36% 49% 20% Spe 98% 95% 87% PPV 35% 76% 80% NPV 98% 85% 29%. In conclusion, in this biased series of patients who were operated on from a PDAC, the value of preoperative imaging “in the real life” is not optimal, particularly regarding arterial and lymph node involvement

Disclosure

All authors have declared no conflicts of interest.