864P - Can the stage and grade of disease be predicted with preoperative peripheral blood parameters in patients with primary urothelial cancer of urinary...

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Urothelial Cancers
Pathology/Molecular Biology
Presenter Abdullah Demirtas
Citation Annals of Oncology (2014) 25 (suppl_4): iv280-iv304. 10.1093/annonc/mdu337
Authors A. Demirtas1, H. Tosun2, V. Sabur2, N. Baydilli2, E.C. Akinsal2, O. Ekmekcioglu2, A. Tatlisen2
  • 1Urology, Erciyes University Faculty of Medicine, 38029 - Kayseri/TR
  • 2Urology, Erciyes University Faculty of Medicine, Kayseri/TR

Abstract

Aim

To assesment relationship between peripheral blood parameters and the stage and grade of the disease in patients with primary urothelial cancer of urinary bladder.

Methods

The study enrolled patients who were diagnosed with primary urothelial cancer and had a white blood cell count if 4000-120000 µL. Patients who had any infection, hematologic disease, and secondary malignancy were excluded. Peripheral blood parameters were obtained from archive files. The stage and grade of the disease was recorded from pathology reports. Statistical analysis was performed using the ROC analysis.

Results

A total 601 patients were included. Pathological tumor stage and grade were significantly correlated with neutrophil count, lymphocyte count, thrombocyte count, and neutrophil-lymphocyte ratio (p < 0.001, p < 0.001; p = 0.007, p = 0.006; p < 0.001, p < 0.001; p < 0.001, p < 0.001, respectively). Cut-off level of neutrophil-lymphocyte ratio for invasiveness in pathological tumor stage was 2.3. This level provided sensitivity, specifity, and positive and negative predictive values of 70.3%, 43.6%, 38%, and 73%, respectively. Cut-off level of neutrophil-lymphocyte ratio for tumor grade was found 2.2.This level was associated with sensitivity, specifity, and positive and negative predictive values of 72.8%, 43%, 53%, and 64%, respectively.

Data of patients
Parameters No, (%)patients
Age (years) 61 (30-88)
Gender
M 527 (87.7)
F 74 (12.3)
Stage
pTa 154(25.6)
pT1 245(40.7)
pT2 147(24.5)
pT3 44 (7.4)
pT4 11(1.8)
Grade
Low 317(52.7)
High 284(47.3)
Follow-up (Months) 32.73(1-123.23)
Mortality 164(27.2)

Conclusions

Neutrophil lymphocyte ratio may be used as a parameter in predicting risk of recurrence and progression in urinary bladder urothelial cancers.

Disclosure

All authors have declared no conflicts of interest.