12P - A molecular case-control investigation of the merkel cell polyomavirus prevalence in Vietnamese non-small-cell lung-cancer

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Metastatic
Cancer Aetiology, Epidemiology, Prevention
Pathology/Molecular Biology
Presenter Trung Ngo
Citation Annals of Oncology (2015) 26 (suppl_1): 1-5. 10.1093/annonc/mdv043
Authors T.T. Ngo
  • Molecular Biology, Tran Hung Dao University Hospital, 0084 - Hanoi/VN

Abstract

Aim/Background

To explore the putative association of the Merkel cell polyomavirus (MCPyV) to the etiology of Non-small-cell lung-cancer.

Methods

A retrospective molecular case–control study was conducted in Non-small-cell lung-cancer patients and their relatives. During the screening program, 106 patient samples (including 77 serum biopsies and 29 parafin embedded tissues) and 90 non-cancer counterparts (50 serum biopsies and 40 parafin embedded tissues) were recruited for being analyzed by realtime-PCR and sequencing.

Results

Our study is the first to demonstrate the presence of Merkel cell polyomavirus DNA in Vietnamese lung cancer with a prevalence of 20.6% cases and less than 1% of controls. This difference was statistically significant and consistent with previous studies.

Conclusions

This difference was statistically significant and consistent with previous studies, hence support a hypothesis that MCPyV is partly associated with the pathogenesis of NSCLC in a subset of Vietnamese patients.

Disclosure

The author has declared no conflicts of interest.