998P - To improve quality of life of reproductive age patients with cervical cancer

Date 29 September 2012
Event ESMO Congress 2012
Session Poster presentation I
Topics Supportive Care
Cervical Cancer
Presenter Visola Navruzova
Authors V. Navruzova
  • Oncogynaecology, National Cancer Center of Uzbekistan, 100174 - Tashkent/UZ

Abstract

Background

Currently, there is a steady increase in the incidence of cervical cancer, especially among young women aged 40 – 44. Along with radical treatment, an important aspect is a quality of life of patients after therapy: 80% of women of reproductive age after ovarioectomy develop postovarioectomic syndrome, which includes the complex of pathological vegetovascular, neuro-psychiatric and metabolic-endocrine disturbances. In this connection there is need for a way to preserve ovarian hormonal activity, so as to ensure the quality of life in women of reproductive age.

Materials and methods

One of the methods to preserve ovarian function is to shield them from radiation zone and it is called transposition. Our study included 189 patients with cervical cancer (CC) T1b-2bN0-1M0 stage (I-III clinical stages) who were examined and treated at the department of Gynecology over 2007 to 2011. 1st group comprised 90 (46.7%) patients, who received complex therapy including surgery with transposition of the ovaries. 2nd group comprised 99 (53.3%) patients, who underwent surgery without ovarian transposition in the complex therapy.

Results

In the main group patients complained of hot flushes - 2% (4 patients), sleep disturbance - 26% (26 patients), sexual dysfunction -19% (23 patients), sweating - 6% (5 patients), pain in bones - 19% (17 patients), weight gain - 29% (26 patients). In the control group there were observed hot flushes - 86% (85 patients), sleep disturbance - 25% (36 patients), sexual dysfunction - 42% (42 patients ), sweating - 19% (19 patients), bone pains 29% (29 patients), weight gain 38% (38 patients). This indicates the more mild post-operative state of patients with ovarian transposition, as well as better tolerance of further anticancer therapy compared with the control group. The study of history data showed that most of the patients symptoms had manifested within 1 to 3 months (in 48.1% of patients), which disappeared after appropriate correction.

Conclusion

Transposition of the ovaries during treatment for cervical cancer in women of reproductive age can improve the quality of life of patients and reduce the terms of social and psychological rehabilitation.

Disclosure

All authors have declared no conflicts of interest.