P-032 - Selenium administration attenuates 5-fluorouracil induced intestinal mucositis

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Complications of Treatment
Supportive Care
Gastrointestinal Cancers
Presenter J.M. Lee
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors J.M. Lee1, H.S. Choi1, H.J. Chun1, I.K. Yoo1, S.H. Kim1, E.S. Kim1, B. Keum1, Y.T. Jeen2, H.S. Lee1, C.D. Kim1
  • 1Korea University College of Medicine, Seoul/KR
  • 2Department of Internal Medicine, Seoul/KR

Abstract

Introduction

Mucositis is a serious complication in patients receiving chemotherapy, and is induced by pro-inflammatory cytokines and reactive oxygen species. Selenium has several metabolic functions, including protection of membrane lipids and macromolecules from oxidative damage. The effect of trace elements against intestinal mucositis after chemotherapy has been rarely investigated. This study aimed to investigate the protective effect of selenium against chemotherapy-induced mucositis in rats.

Methods

Twenty-four female Wistar rats were randomly allocated to four groups: control; selenium; 5-fluorouracil (5-FU); 5-FU plus selenium. Mucositis was induced by single dose of 5-FU (400 mg/kg) by intraperitoneal injection. Selenium supplementation was administered by single dose of sodium selenite (0.2 mg/kg) by intraperitoneal injection.

Results

Diarrhea and weight loss after 5-FU administration was attenuated by selenium treatment. The degree of damage to the intestinal villi in rats treated with 5-FU and selenium supplementation was lesser than that in rats treated with 5-FU alone (p < 0.05 vs. 5-FU). The mRNA of IL-1ß and TNF-α were significantly decreased in the group treated with 5-FU and selenium compared with those in the group treated with 5-FU alone (IL-1ß, p < 0.01 vs. 5-FU; TNF-α, p < 0.05 vs. 5-FU).

Conclusion

Selenium has a beneficial effect in protecting the mucosa during chemotherapy. This protective effect is attributed to its anti-inflammatory effects and the selenium-induced suppression of cytotoxic cytokines.