1505P - Safety of chemotherapy recycling in solid tumor patients with an absolute neutrophil count (ANC) under 1500/mm3

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anti-Cancer Agents & Biologic Therapy
Supportive Care
Presenter Mirela Souto
Citation Annals of Oncology (2014) 25 (suppl_4): iv517-iv541. 10.1093/annonc/mdu356
Authors M. Souto1, A. Ferreira2, M. Alves3, K.T. Souza3, L. Testa4, M. Braghiroli4, R.R. Munhoz4, P.M. Hoff4
  • 1Oncology, Hospital Sirio Libanês, 01308050 - sao paulo/BR
  • 2Oncology, Hospital Sirio Libanes, Sao Paulo/BR
  • 3Oncology, Instituto do Cancer do Estado de Sao Paulo, sao paulo/BR
  • 4Oncology, Hospital Sirio Libanês and Instituto do Cancer do Estado de Sao Paulo, sao paulo/BR

Abstract

Aim

Neutropenic fever is one of the major causes of morbidity and mortality in patients receiving cancer treatment. An ANC of at least 1500/ mm3 is usually required for chemotherapy administration, and dose reductions and delays caused by a low neutrophil counts may potentially impact on outcomes. Surprisingly, there is no clear evidence of what ANC cut-off value should actually be used in clinical practice. The aim of this study was to assess the clinical outcomes in patients receiving chemotherapy with ANC less than 1500/ mm3 compared to those with normal ANC.

Methods

In this bi-institutional retrospective study, we evaluated 157 consecutive patients with solid tumors and compared clinical outcomes (neutopenic fever, delay or dose reduction of chemotherapy, antibiotic use and hospitalization) between two groups according to their ANC: either under, but at least 1000/mm3, or above 1500/mm3 before the beginning of each cycle.

Results

A total of 155 patients were analyzed. Among patients who had their treatment delayed in the second cycle, 4 (44,4%) had less than 1500/mm3 and 5 (55.6%) had more than 1500/mm3 on the beginning of each cycle (HR for treatment delay: 0.88; p = 0.84). The respective values for the third cycle were 5 (55.6%) and 4 (44.4%), (HR= 0.51; p = 0.29). The hazard ratios for fever, need of antibiotic and hospitalization were 1.93 (p = 0.22), 1.97 (p = 0.15) and 1.27 (p = 0.65) in the 2nd cycle and 1.76 (p = 0.3), 2.4 (p = 0.08) and 2.35 (p = 0,15) in the 3rd one.

Conclusions

Patients with solid tumors who received chemotherapy with ANC less than 1500/mm3 did not seem to have a worse clinical outcomes compared to patients with higher counts. Regarding the rates of fever, need of antibiotic, hospitalization and treatment delayed, there was not a statistically significant difference between the two groups.

Disclosure

All authors have declared no conflicts of interest.