1446 - Vitamin D deficiency in terminal cancer patients admitted to hospice care clinic in Korea

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Palliative Care
Presenter Hyun-jeong Shim
Authors H. Shim1, S. Cho2, D.E. Kim1, J.E. Hwang1, W.K. Bae1, I.J. Chung3
  • 1Department Of Internal Medicine, Chonnam National University Medical School, 519-809 - Gwangju/KR
  • 2Internal Medicine Hemato-oncology, Chonnam National University Medical School, 519-809 - Gwangju/KR
  • 3Medical Oncology, Chonnam National University Medical School, 519-809 - Gwangju/KR

Abstract

Background

The prevalence of vitamin D deficiency in patients with terminal cancer is not well documented. The objective of this report was to describe and understand vitamin D status in terminal cancer patients.

Methods

A total of 67 consecutive terminal cancer patients who were in the Hospice and Palliative Care Clinic at Jeonnam Regional Cancer Center during Aug 2011 to Mar 2012 were analyzed in this study. We investigated serum levels of 25(OH) vitamin D, calcium, albumin and c-reactive protein. We also evaluated clinical characteristics, common symptoms including delirium, depression, fatigue and pain.

Results

The median age of patients was 58 years, and 64.2% were men. Gastrointestinal (47.8%) cancer, hepatobiliary & pancreatic cancer (26.9%) and lung (13.4%) cancer were predominant. Sixty patients (89.6%) were vitamin D deficient (<20 ng/mL), 5 (7.5%) were insufficient (20-30ng/mL) and only 2 (3%) were suffienct (>30 ng/mL). The level of vitamin D of 37 patients (55.2%) were less than 10ng/mL. Low serum vitamin D levels were independent of age, gender, primary disease site, body mass index, history of chemotherapy and disease duration. No significant association was found between vitamin D and symptoms such as delirium, depression, fatigue and pain.

Conclusions

Vitamin D deficiencies were very common and severe in hopice population. There was no significant association between vitamin D levels and clinical factors. And also, we could not find a relation between vitamin D levels and symptoms including delirium, depression, fatigue and pain.

Disclosure

All authors have declared no conflicts of interest.