1409 - Neoplasic disease and chronic kidney disease: does the association worsen prognosis?

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Palliative and Supportive Care
Presenter Daniel Romeira
Authors D. Romeira1, C.T. Carvalho2, M. Proença3, M. Alface3, R. Cardiga3, R. Ferreira3, A. Leitão3, C. Fonseca3, F. Ceia3, A.M. Martins2
  • 1Medical Oncology Unit, Hospital são Francisco Xavier, 1495-005 - Lisboa/PT
  • 2Medical Oncology Unit, Hospital São Francisco Xavier, 1495-005 - Lisboa/PT
  • 3Internal Medicine, HSFX, 1300 - Lisboa/PT

Abstract

Neoplastic diseases (ND) and chronic kidney disease (CKD) are strongly related. Side effects of neoplastic treatments can cause CKD and the latter can be a risk factor for ND. Even in early stages of CKD, the risk of developing ND increases, the latter being drastically increased in patients (pts) treated with hemodialysis.

Objectives

Compare, within a population of cancer pts with and without CKD, demographic characteristics, length of hospital stay, and prognosis.

Methods

Observational prospective study with all consecutively admitted pts in an Internal Medicine department of a CentralHospital between November 2010 and October 2011. Collection of data using a previously normalized questionnaire, completed on admission and date of release, finalized with a posterior telephonic contact. The following characteristics of pts with ND and CKD (GFR CKD < 60 mL/min/1,73m2) - GROUP A (GA) and with ND but without CKD - GROUP B (GB) were compared: demographics, in-hospital evolution, hospital stay and post-release mortalities

Results

We evaluated 104 pts with ND with an average follow-up of 162 days.GA= 40 pts (38,5%) 78,9 ± 10,6 years, 52,5% women, GFR =39,6 ±12 mL/min/1,73m2, stages III = 77,5%, IV = 22,5% GB= 64 pts (61,5%), 72,92 ± 12,6 years; 46,9% women, GFR = 72,9 ± 14,5mL/min/1,73m2. Hospital stay length: GA 9,2 ± 5 vs GB 9.9 ± 9,3 days. Hospital stay mortality: GA: 27,5% VS GB: 3,125%. CKD correlates with hospital-stay mortality: (?2(2) = 13,371; p = 0,000 N = 104.); Significant differences were found between both groups pertaining to average survival during follow-up: (t(52) = -3,437; p = 0,01). The average length of hospital-stay and the number of readmissions are not related to the existence of CKD: (?2(2) = 0,399; p = 0,53 N = 90)

Conclusion

More than 1/3 of ND pts had CKD, the majority within stage III. ND pts with CKD were older. CKD contributed to hospital stay mortality and shorter survival rate on follow-up of pts with ND but did not contribute to an increase of hospital stay length.

Disclosure

All authors have declared no conflicts of interest.