957P - Hepatic toxicity and outcome in HCV-positive patients with diffuse large B-cell lymphoma treated with rituximab-based chemotherapy

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anti-Cancer Agents & Biologic Therapy
Complications of Treatment
Lymphomas
Cancer in Special Situations
Presenter Manal Salah El Din
Citation Annals of Oncology (2014) 25 (suppl_4): iv327-iv339. 10.1093/annonc/mdu339
Authors M. Salah El Din1, M.A. Ebrahim1, W. El-Sadda2
  • 1Medical Oncology, Oncology Center, Mansoura University, 2123 - Mansoura/EG
  • 2Clinical Oncology And Nuclear Medicine, Mansoura University Hospital School of Medicine, 35511 - Mansoura/EG

Abstract

Aim

The influence of rituximab therapy on prognosis and hepatic toxicity (HT) in patients with hepatitis C virus (HCV) positive diffuse large B-cell lymphoma (DLBCL) is unclear. Thus, we aimed to assess HT and clinical outcome in patients with DLBCL and HCV infection who received rituximab containing immunochemotherapy.

Methods

We carried out a prospective analysis on a total of 280 HCV-positive patients with DLBCL, 200 of whom received chemotherapy plus rituximab (R-CHT), 80 received chemotherapy (CHT)-only. Survival outcomes and HT were compared according to rituximab administration.

Results

The median follow-up was 41 months. Addition of rituximab did not significantly affect prognosis (median progression-free survival, 40 vs 35 months, P =.26; median overall survival, 51 vs 43 months P =.09). Of 200 patients who received rituximab, 53 (26.5%) had severe HT (grade 3-4), compared with 11 of 80 (13.75%) patients who received rituximab-free regimens (P = .033). Among patients treated with rituximab; 50 patients (25%) did not complete planned course of therapy, 14 patients because of hepatic toxicity and 36 patients because of progressive disease. Pretreatment liver function impairment was predictive of severe HT.

Conclusions

These results suggest that HCV-positive DLBCL patients do not drive anti-lymphoma benefit from the addition of rituximab due to occurrence of HT that caused significant limitation in the delivery of effective immunotherapy. Specific clinical approach is needed to limit HT and ameliorate survival in this group of patients.

Disclosure

All authors have declared no conflicts of interest.