1496P - Attitudes of physicians toward risk assessment and use of granulocyte-colony stimulating factor (G-CSF) as primary prophylaxis (PP) in patients (pt...

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Complications of Treatment
Supportive Care
Bioethics, Legal, and Economic Issues
Presenter Gilles Freyer
Citation Annals of Oncology (2014) 25 (suppl_4): iv517-iv541. 10.1093/annonc/mdu356
Authors G. Freyer1, E. Kalinka-Warzocha2, K. Syrigos3, M. Marinca4, G. Tonini5, S.L. Ng6, Z.W. Wong7, A. Salar8, G.G. Steger9, M. Abdelsalam10, L. Decosta11, Z. Szabo12
  • 1Department Of Medical Oncology, CHU de Lyon, 69495 - Lyon/FR
  • 2Chemotherapy Department, Wojewodzki Szpital Specjalistyczny im. M. Kopernika, Lodz/PL
  • 3Oncology Unit,, Sotiria General Hospital, Athens School of Medicine, Athens/GR
  • 4Department Of Oncology, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi/RO
  • 5Department Of Oncology, University Campus Bio-Medico of Rome, Rome/IT
  • 6Oncology Unit, Bendigo Health Care Group, Bendigo/AU
  • 7Oncology Unit, Goulburn Valley Health, The University of Melbourne, Melbourne/AU
  • 8Department Of Clinical Hematology, Hospital del Mar, Barcelona/ES
  • 9Department Of Medicine I/oncology, Medical University of Vienna, AT-1090 - Wien/AT
  • 10Medical Oncology Department, Moncton City Hospital, Moncton/CA
  • 11Biostatistics, Amgen Ltd, Uxbridge/GB
  • 12Medical Affairs, Amgen (Europe) GmbH, Zug/CH

Abstract

Aim

For chemotherapy regimens with intermediate FN risk (10–20%), physicians should assess patient risk factors to determine whether overall risk is >20% and G-CSF PP is indicated1. This study described factors considered important by physicians when assessing FN risk and deciding to use G-CSF PP in pts receiving intermediate-FN-risk chemotherapy.

Methods

This prospective observational study (NCT01813721) was conducted in Europe, Australia and Canada. Before pt enrolment, investigators reported their own FN risk threshold at which they usually give G-CSF PP, and selected and ranked factors they considered important when assessing overall FN risk and deciding to give G-CSF PP (investigator baseline assessment). For each enrolled pt, their overall FN risk score and the same factors were assessed before starting chemotherapy (patient assessment), and whether G-CSF PP was planned was reported.

Results

The final analysis included 165 investigators (67% medical oncologists) and 944 pts (median age 61 years, range 20–94) with breast cancer (42%), lung cancer (39%) or NHL (19%). Stage IV disease was reported in 34% of pts; 1% had a history of FN. Table 1 lists factors most often ranked for FN risk assessment and G-CSF PP decision. The median investigator-reported FN risk threshold was 20% and the pt median overall FN risk score was 18%. G-CSF PP was planned in 82% pts with an overall FN risk score≥the investigator's threshold and in 19% pts with an overall risk score

Top 5 most frequently listed factors deemed important by investigators in the overall FN risk assessment and the G-CSF PP decision, at baseline and for each individual patient

Factors considered in overall FN risk assessment, % (95% CI) Factors considered in G-CSF PP decision, % (95% CI)
Investigator assessment (n = 165) Patient assessment (n = 944) Investigator assessment (n = 165) Patient assessment (n = 944)
Chemotherapy agents in the backbone 88 (82–93) Chemotherapy agents in the backbone 93 (88–96) Outcome of FN risk assessment 89 (83–93) Outcome of FN risk assessment 79 (71–84)
Prior history of FN 83 (76–89) Tumour type 72 (61–82) Age 80 (71–87) Guidelines 67 (53–79)
Baseline laboratory values 76 (68–83) Guidelines 62 (48–74) Baseline laboratory values 74 (64–82) Treatment intent 67 (59–74)
Age 73 (64–81) Tumour stage 43 (34–53) Guidelines 71 (61–78) Age 51 (43–60)
Prior chemotherapy 71 (62–78) Age 39 (32–48) Treatment intent 69 (61–77) ECOG/Karnofsky performance status 36 (28–45)

CI, confidence interval; ECOG, Eastern Cooperative Oncology Group.

Conclusions

The most frequently considered factors were chemotherapy regimen for assessing FN risk and FN risk assessment outcome for decision to initiate G-CSF PP. Other factors were selected less consistently at the investigator and pt level. A standardised approach to risk factor assessment may improve guideline adherence and G-CSF use. 1Aapro et al. (2011) Eur J Cancer;47:8–32

Disclosure

G. Freyer: Consultant for Amgen France; E. Kalinka-Warzocha: Received honoraria from Amgen for clinical trials. Given lectures for Amgen; M. Marinca: Has spoken in speaker bureaus for Amgen Romania; L. Decosta: Employed by Amgen and holds stock; Z. Szabo: Employed by Amgen and holds stock. All other authors have declared no conflicts of interest.