1650P - The clinical and pathological significance of cyclooxygenase-2 (COX-2) and human antigen receptor (HuR) expression in non small cell lung cancers

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Nikolaos Tsoukalas
Citation Annals of Oncology (2014) 25 (suppl_4): iv564-iv573. 10.1093/annonc/mdu359
Authors N.G. Tsoukalas1, C. Giaginis2, P. Alexandrou2, M. Tolia2, E. Bournakis2, A. Papakostidi2, I. Sfiniadakis3, N. Kavantzas2, E. Agapitos2, E. Patsouris2, S. Theocharis2
  • 1Medical Oncology, 401 General Military Hospital, 11524 - Athens/GR
  • 2Medical School, National and Kapodistrian University of Athens, Athens/GR
  • 3Pathology, Navy Hospital, Athens/GR

Abstract

Aim

Cyclooxygenase-2 (COX-2) is implicated in tumor proliferation, angiogenesis, tumor invasiveness, cell-mediated immunity and resistance to apoptosis. Hu-antigen R (HuR) is also considered to play a central role in tumor formation, growth and metastasis by binding to mRNAs encoding proteins such as COX-2. The present study aimed to evaluate the clinical significance of COX-2 and HuR protein expression in non-small cell lung cancers (NSCLC).

Methods

COX-2 and HuR expression was assessed immunohistochemically on tissue microarrays of 81 surgically resected NSCLC and was analyzed in relation with clinicopathological characteristics and patients' survival.

Results

Enhanced COX-2 expression was significantly associated with the presence of lymphovascular invasion and increased tumor proliferative capacity (p=0.031 and p=0.023, respectively). Enhanced total HuR expression was significantly associated with tumour histopathological type and presence of lymph node metastases, as well as, with increased tumour proliferative capacity and poor patients' outcome (p=0.039, p=0.017, p=0.033 and p=0.022, respectively). Concomitant elevated expression levels of HuR and COX-2 were significantly associated with tumour histopathological type and increased tumor proliferative capacity (p=0.002 and p=0.045, respectively). Enhanced total HuR expression was significantly associated with increased COX-2 expression (p=0.015).

Conclusions

The present study supported evidence that COX-2 and HuR may have a role in the malignant transformation and growth of NSCLC. Particularly, COX-2 and HuR could be considered as potential biomarkers indicating tumor aggressiveness. Nevertheless, more studies are needed to elucidate their clinical significance.

Disclosure

All authors have declared no conflicts of interest.