2O - Significance of lepidic growth component in the discrimination of multiple primary lung cancers from intrapulmonary metastases

Date 27 March 2014
Event ELCC 2014
Session Proffered Papers 2 - Tumour biology and translational research
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Dongmei Lin
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors D. Lin1, W. Sun1, Y. Liu2, X. Liu2, L. Shan2, X. Yang2
  • 1Department Of Pathology, Cancer Institute and Hospital of the Chinese Academy of Medical Sciences, Beijing/CHINA, 100000 - beijing/CN
  • 2Department Of Etiology And Carcinogensis, Peking Union Medical College, Cancer Institute and Hospital of the Chinese Academy of Medical Sciences, Beijing/CHINA, beijing/CN

 

Abstract

The distinction of intrapulmonary metastases from multiple primaru tumors is of great clinical importance as it influences staging, prognosis and therapeutic strategy. Although Comprehensive Assessment (CHA) was recommended by IASLC/ATS/ERS to differentiate multiple lung primary non-small cell carcinoma from metastases, the limitaitons of CHA have been addressed. Lung adeocarcinoma in situ is characteried by noninasive lepidic growth. Whether this histological characterized by noninvasive lepidic growth. Whether this histological characteristic could be served for assessing primary lung cancer has not been well determined. In this study, we evaluated the applicaion value of CHA and lepidic growth component (LGC) in ditinguishing multiple primary lung cancers from intrapulmonary metastass.