1631P - Prognostic value of total lesion glycolysis and metabolic tumor volume in non-small cell lung cancer

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Karolien Vanhove
Citation Annals of Oncology (2014) 25 (suppl_4): iv564-iv573. 10.1093/annonc/mdu359
Authors K. Vanhove1, M. Heylen1, R. Derwael1, E. Louis1, M. Thomeer2, L. Mesotten3, P. Adriaensens4, R. Boellaard5
  • 1Faculty Of Medicine And Life Sciences, Hasselt University, 3590 - Diepenbeek/BE
  • 2Respiratory Medicine, ZOL St. Jan Genk, 3600 - Genk/BE
  • 3Nuclear Medicine, Ziekenhuis Oost-Limburg, 3600 - Genk/BE
  • 4Institute For Materials Research, Hasselt University, 3590 - Diepenbeek/BE
  • 5Nuclear Medicine, VUMC, Amsterdam/NL

Abstract

Aim

To predict the outcome of patients with NSCLC the currently used prognostic system (TNM) is not accurate enough.The prognostic significance of SUV measured by PET remains controversial. This retrospective study aims to evaluate the prognostic value in overall survival (OS) and progression free survival (PFS) of the standard uptake value(SUV), total lesion glycolysis(TLG) and the metabolic volume (MTV) in primary NSCLC.

Methods

This study investigates 86 patients (58 male, 28 female) with a new diagnosis of NSCLC (TNM stage I : 24.4%, II:9.3%,III:38.4% and IV:27.9%) who underwent PET/CT.For VOI definition a semi-automatic delineation tool was used. On PET images SUVmax,SUVmean and MTV of the primary tumors were measured. PET parameters were corrected for lean body mass and glycemia.TLG was defined as SUVmean*MTV.TLG50 was calculated by using a treshold of 50% of the SUVmax.SUV index was calculated as the ratio of tumor SUVmax to liver SUVmean to improve reproducibility and to lower the influence of patient and scanner related factors.

Results

Median follow up was 17 months.Pre-therapy median MTV,TLG50 and SUVmax were 10.37 +- 47.01 ml, 52.49 +- 239.33ml and 7.67+-5.55 respectively.OS and PFS were significantly higher in patients with values below the median values of MTV, TLG50 and SUVmax.Univariate analysis revealed gender(HR 0.3 95%CI 0.14-0.65 for OS and HR 0.33 95%CI 0.17-0.64 for PFS) and stage (HR 2.22 95%CI 1.58-3.11 for OS and HR 2.0 95%CI 1.5-2.68 for PFS) as additional prognostic factors. Multivariate analysis revealed that TLG50 (HR 2.15 95%CI 1.41-4.04), stage (HR 2.16 95%CI 1.52-3.06) and gender (HR 0.32 95%CI 0.15-0.70) were independent prognostic factors for OS.The same parameters were significant for PFS :TLG50 (HR 2.08 95%CI 1.15-3.73), stage (HR 2.1 95%CI 1.54-2.86) and gender (HR 0.28 95%CI 0.14-0.55).MTV and SUV index were not found to be significant in our multivariate model.

Conclusions

Our study indicates that TLG50 of the primary tumor is an independent prognostic factor in patients with NSCLC for both OS and PFS. Further stratification of patients with the same TNM stage by TLG50 may improve outcome. Prospective studies and validation are needed for determination of the optimal cutoff value before transferring results into clinical practice.

Disclosure

All authors have declared no conflicts of interest.