22P - PEGylated γ-Fe2O3-Nanocrystal from goat red blood cells enhances the nuclear-targeted delivery of doxorubicin in lung cancer therapy

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Vellingiri Sreevani
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors V. Sreevani1, K. Shanthi1, S. Kannan2
  • 1Zoology, Bharathiar University, 641046 - Coimbatore/IN
  • 2Zoology, Periyar University, 636011 - Salem/IN

Abstract

• To synthesis DOX loaded PEGylated γ-Fe2O3-NC using goat blood as a bio-precursor (Molecular approach).

• To exhibit potent cytotoxicity against A549 and iron detection by Prussian blue stain.

• To detect apoptosis by Ao/EtBr and nuclear fragmentation by DAPI.

• To study DOX signal detection implies nuclear targeting.

• To observe cellular internalization of nanocrystals.