117P - Whole brain radiotherapy with concurrent temozolomide for brain metastasis in non-small cell lung cancer: a single institution, open labeled randomi...

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Anti-Cancer Agents & Biologic Therapy
Non-Small-Cell Lung Cancer, Metastatic
Surgery and/or Radiotherapy of Cancer
Presenter Sanudev Vadakke Puthiyottil
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors S.S. Vadakke Puthiyottil, B.S. Mathew, P.G. Jayaprakash, C.D. Sivanandan, K. Ratheesan
  • Radiation Oncology, Regional Cancer Centre Thiruvananthapuram, 695011 - Trivandrum/IN


The mainstay of treatment for multiple Brain metastases (BM) is fractionated whole brain radiotherapy (WBRT). Concurrent Temozolomide (TMZ) with WBRT has been reported to improve response rates with non-significant prolongation of median survival. This study was intended to assess the efficacy of WBRT + TMZ in improving neurological progression free survival (PFS) for newly diagnosed patients with BM from Lung cancer.