1321P - Imaging characteristics associated with driver mutations in patients with non-small-cell lung cancer

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Non-Small-Cell Lung Cancer, Metastatic
Imaging, Diagnosis and Staging
Translational Research
Presenter Jangchul Park
Citation Annals of Oncology (2014) 25 (suppl_4): iv426-iv470. 10.1093/annonc/mdu349
Authors J. Park1, H. Yamaura2, Y. Yatabe3, Y. Oya1, K. Tanaka1, T. Oguri1, T. Yoshida1, J. Shimizu1, Y. Horio1, T. Hida1
  • 1Thoracic Oncology, Aichi Cancer Center Hospital, 4648681 - Nagoya/JP
  • 2Diagnostic And Interventional Radiology, Aichi Cancer Center Hospital, 4648681 - Nagoya/JP
  • 3Pathology And Molecular Diagnostics, Aichi Cancer Center, 46488681 - Nagoya/JP

Abstract

Aim

The purpose of this study is to better identify imaging characteristics on computed tomography (CT) in patients with non-small-cell lung carcinoma (NSCLC) with known epidermal growth factor receptor (EGFR) mutations, KRAS mutations, and anaplastic lymphoma kinase (ALK) gene rearrangements.

Methods

Two hundred fifty-seven patients with a diagnosis of NSCLC and EGFR mutations, KRAS mutations or ALK gene rearrangements were assessed. We retrospectively analyzed the CT characteristics of each cohort.

Results

We evaluated 257 patients with NSCLC. One hundred fifty-three patients (59.5%) had EGFR mutations, 54 patients (21.0%) had KRAS mutations, and 50 (19.5%) had ALK gene rearrangements. All mutations were mutually exclusive. Most patients had stage III or IV disease. One hundred twenty-one cases were male, and 136 were female. The mean age was 62.1 years (range29-89). Patients with EGFR mutations tend to have ground grass opacity (GGO), air bronchograms, and lung metastases (p< 0.0001, p= 0.0189, p= 0.0028 respectively). Conversely, the lack of GGO components, air bronchograms, lung metastases, and pleural effusions is correlated with KRAS mutations. (p= 0.0084, p= 0.0082, p= 0.0016, and p= 0.0052 respectively). Smaller size of tumor (< 3cm), the lack of any GGO components, and the presence of lymphadenopathy, lymph nodes with extranodal invasion, lymphangitis and pleural effusions were significantly associated with the presence of ALK gene rearrangements (p= 0.0166, p= 0.0004, p= 0.0074, p= 0.0089, p= 0.0266, p= 0.0296 respectively).

Conclusions

These findings may help to make a proper diagnosis in the current era of molecular targeted therapies.

Disclosure

All authors have declared no conflicts of interest.