80P - Role of treatment in international differences in one-year mortality from early stage non-small cell lung cancer: A tentative answer from the Intern...

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Early Stage
Presenter Tsion Solomon
Citation Annals of Oncology (2015) 26 (suppl_1): 18-23. 10.1093/annonc/mdv048
Authors T. Solomon1, M.D. Peake2, J. Butler3, M.P. Coleman1, W.K. Evans4, E. Jakobsen5, M. Boyer6, T.B. Johannesen7, B. Rachet1
  • 1Department Of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, WC1E 7HT - London/UK
  • 2Department Of Respiratory Medicine, Glenfield Hospital, - - Leicester/UK
  • 3Royal Marsden Hospital, Royal Marsden Hospital, London/UK
  • 4Juravinski Cancer Centre At Hamilton Health Sciences, Cancer Care Ontario, Toronto/CA
  • 5-, Odense University Hospital, - - Odense C/DK
  • 6Sydney Cancer Centre, Royal Prince Alfred Hospital, - - Sydney/AU
  • 7-, Norwegian Cancer Registry, - - Oslo/NO

Abstract

Aim/Background

International differences in lung cancer survival are well known. Using population-based data, we assessed if variation in the provision of treatment may explain some of this variation, focusing on early-stage non-small cell lung cancer (NSCLC) where guidelines recommend resection of curative intent.

Methods

Population-based registry data were obtained for all 6,375 adults diagnosed with early-stage NSCLC during 2004-2006 in Australia (New South Wales), Canada (Manitoba), Denmark, Norway and the UK (East of England, West Midlands), and merged with surgery information. Age- and sex-adjusted logistic regression models were fitted considering surgery of curative intent and death within one year since diagnosis as distinct outcomes.

Results

Patients in Norway, Manitoba and West Midlands had higher adjusted odds of receiving surgery of curative intent (range: OR = 1.40-1.51) and lower odds of dying within one year after diagnosis (OR = 0.59-0.83). The converse was found in East of England and New South Wales (surgery: OR = 0.45-0.54; dying within one year after diagnosis: OR = 1.49-1.56). In Denmark there was an unusual higher likelihood of both surgery of curative intent and early death.

Conclusions

Higher likelihood of surgery of curative intent was generally associated with better short-term prognosis in this large population-based study. Improving access to surgical treatment would probably reduce the survival gap among patients with early-stage NSCLC.

Disclosure

All authors have declared no conflicts of interest.