76P - Result of the 6-minute walk test is an independent prognostic factor of surgically treated non-small cell lung cancer

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Early Stage
Surgery and/or Radiotherapy of Cancer
Presenter Tomasz Marjanski
Citation Annals of Oncology (2015) 26 (suppl_1): 18-23. 10.1093/annonc/mdv048
Authors T. Marjanski1, M. Badocha2, D. Wnuk3, A. Mosiewicz4, W. Rzyman1
  • 1Thoracic Surgery Department, Medical University of Gdansk, 80-214 - Gdansk/PL
  • 2Faculty Of Applied Physics And Mathematics, Technical University of Gdansk, 80-233 - Gdansk/PL
  • 3Department Of Physical Therapy, Medical University of Gdansk, 80-211 - Gdansk/PL
  • 4Chair Of Anaesthesiology And Intensive Care, Medical University of Gdansk, 80-214 - Gdansk/PL

Abstract

Aim/Background

Pathological TNM (pTNM) remains the most significant prognostic factor of non-small cell lung cancer (NSCLC). Age, gender, pulmonary function tests, the extent of surgical resection and presence of concomitant diseases are commonly used to complete the profile of the patient with early stage of NSCLC. The aim of the study was to assess the influence of the result of 6-minute walk test (6MWT) on the prognosis of patients with surgically treated NSCLC.

Methods

Between April 2009 and October 2011, 624 patients who underwent surgical treatment due to NSCLC entered this study. All the patients were qualified for resection on the basis of standard evaluation protocol. Additionally on the day before the surgery patients performed 6-minute walk test (6MWT). Threshold values of 6MWT were assessed on the basis of Akaike Information Criterion and coefficient of determination R2. Stepwise logistic regression was used to analyse the effect of prognostic factors on overall survival.

Results

There were 390 men and 234 women with a mean age of 64 years. All patients underwent radical surgical treatment due to primary lung cancer. There were 525 lobectomies (84%), 77 pneumonectomies (12%) and 24 (4%) lesser resections. First stage of NSCLC was the reason for treatment in 331 patients (53%), stage II in 191 patients (31%) and stages IIIA-IV in 102 patients (16%). Distance of 525 meters (HR = 0,56 95%CI:0,41-0,78 p < 0,001) occurred to be the threshold value differentiating the patients' prognosis (p < 0,001). In a logistic regression analysis pTNM stage (IIA HR = 1,87 95%CI:1,95-2,92 p = 0,006; IIB HR = 2,03 95%CI:1,23-3,37 p = 0,005; IIIA-IV HR = 2,36 95%CI:1,49-3,75 p < 0,001), male sex (HR = 1,88 95%CI:1,26-2,79 p = 0,001), pneumonectomy (HR = 1,78 95%CI:1,17-2,70 p < 0,001) and result of 6MWT (HR = 0,50 95%CI:0,36-0,70 p < 001) were independent factors influencing survival.

Conclusions

Result of the 6-minute walk test is an independent prognostic factor of surgically treated non-small cell lung cancer.

Disclosure

All authors have declared no conflicts of interest.