57P - Mucin 1 (MUC1) expression in patients (pts) with early stage non-small cell lung cancer (NSCLC): relationship between immunohistochemistry (IHC) in...

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Non-Small-Cell Lung Cancer, Early Stage
Translational Research
Presenter Paul Mitchell
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors P.L.R. Mitchell1, K. Asadi2, T. John1, C. Murone3, S. Knight4
  • 1Ludwig Medical Oncology Unit, Olivia Newton-John Cancer and Wellness Centre, Austin Health, 3084 - Melbourne/AU
  • 2Anatomical Pathology, Austin Health, 3084 - Melbourne/AU
  • 3Anatomical Pathology, Austin Health and Ludwig Institute for Cancer Research, 3084 - Melbourne/AU
  • 4Thoracic Surgery, Austin Health, 3084 - Melbourne/AU


MUC1, a glycoprotein highly expressed in many malignancies, is being explored as an antigen for immunotherapy. Although MUC1 expression on IHC is very frequent In NSCLC (Mitchell et al. Proc ASCO 2013, abs 3011) and circulating sMUC1 may be elevated, the relationship has been poorly studied. This study explored the relationship between MUC1 IHC and plasma sMUC1 in patients undergoing lobectomy or pneumonectomy for NSCLC.