168P - Malignant pleural effusion biomarkers as predictor for chemical pleurodesis success

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Supportive Care
Lung and other Thoracic Tumours
Translational Research
Presenter Sherif Alsayed
Citation Annals of Oncology (2015) 26 (suppl_1): 51-54. 10.1093/annonc/mdv053
Authors S.R. Alsayed
  • Chest, EL Fayoum University, 002 - Cairo/EG

Abstract

Aim/Background

This study aimed to evaluate the value of biochemical parameters of the pleural aspirate in predicting success of chemical pleurodesis in adult patients with malignant pleural effusion.

Methods

This prospective study included 30 adult patients with malignant pleural effusion diagnosed by clinical examination, Chest CT scanning and closed pleurocentesis. Patient ages mean of 60.4 ± 7.8 years, multiple sessions of closed pleurocentesis were carried out followed by insertion of an intercostal tube. The pleural aspirate was then sent for chemical analysis to detect Glucose, PH, and LDH., pleurodesis was then done either by using Tetracycline (group A, or Bleomycin (group B). All patients were then followed up for success of the pleurodesis process within one month.

Results

Within one month of follow-up, rates of clinical response to treatment in group A (Tetracycline) were successful in (40 %); versus group B (73.3 %). Complete response (CR) occurred in group A cases (20 %); versus (33.3 %) in group B; whereas partial response (PR) occurred in 3 cases of group A; versus 6 cases of group B; and treatment failure (TF) occurred in 9 of group A cases versus 4 of group B case. None of our patients died. Morbidity occurred in the form of mild-to-moderate. The success of the pleurodesis was closely-associated to a higher glucose and PH levels together with a low LDH level in the pleural fluid.

Conclusions

The success of pleurodesis is usually higher when the pleural fluid PH and glucose levels are high & the LDH level is low in MPE.

Disclosure

The author has declared no conflicts of interest.